- Open Access
Update to “guidelines on COVID-19 vaccination in patients with immune-mediated rheumatic diseases: a Brazilian Society of Rheumatology task force”
Advances in Rheumatology volume 62, Article number: 29 (2022)
The Committee of Endemic and Infectious Diseases and the Executive Board of the Brazilian Society of Rheumatology (SBR) proposed an update to the “Guidelines on COVID-19 vaccination in patients with immune-mediated rheumatic diseases: a Brazilian Society of Rheumatology task force”  based on recently published scientific evidence  and on the new recommendations of the Brazilian National Immunization Program (NIP) for vaccination of immunocompromised persons [3, 4]. According to the NIP documents [3, 4], the primary vaccination series is composed of three doses of Coronavac or ChAdOx-1 (AstraZeneca) or mRNA BNT162b2 (Pfizer), or two doses of Ad26.COV2.S (Janssen). A booster is recommended four months after the primary vaccination schedule, preferably with an mRNA vaccine or a non-replicating viral vector. The NIP recommendations for immunocompromised patients, endorsed by the SBR, are summarized below:
An 8-week interval between the second and third doses was chosen over a shorter interval of 3 weeks to potentiate vaccine responses and minimize possible adverse events ;
Persons 18 years and older who received the three-dose primary vaccination series should receive a fourth booster dose four months after the third, preferably with AstraZeneca, Janssen or Pfizer ;
Persons 18 years and older who received one dose Janssen vaccine should complete the primary vaccination series with a second dose of the Janssen vaccine eight weeks after the first dose and receive a third booster dose four months after the second dose, preferably AstraZeneca, Janssen, or Pfizer ;
Pregnant and postpartum women (up to 45 days following end of pregnancy) should receive a booster dose four months after the primary vaccination series of Pfizer vaccine and, if not available, Coronavac vaccine ;
Adolescents from 12 to 17 years old should receive three doses in the primary vaccination series and a fourth booster dose Pfizer four months after the third one ;
Children from 5 to 11 years old should receive the Pfizer two-dose primary vaccination series with an 8-week interval between the first and second doses .
Availability of data and materials
Brazilian Society of Rheumatology
National Immunization Program
Tavares ACFMG, Melo AKG, Cruz VA, Souza VA, Carvalho JS, Machado KLLL, et al. Guidelines on COVID- 19 vaccination in patients with immune- mediated rheumatic diseases: a Brazilian Society of Rheumatology task force. Adv Rheumatol. 2022;62:3. https://doi.org/10.1186/s42358-022-00234-7.
Bar-On YM, Goldberg Y, Mande M, Bodenheimer O, Freedman L, Kalkstein N, et al. Protection of BNT162b2 vaccine booster against COVID-19 in Israel. N Engl J Med. 2021;385:1393–400. https://doi.org/10.1056/NEJMoa2114255.
MINISTÉRIO DA SAÚDE. Nota Técnica nº 8/2022- SECOVID/GAB/SECOVID/MS: Recomendação para administração do esquema primário e dose de reforço de vacinas contra a COVID-19 em pessoas imunocomprometidas a partir de 12 anos de idade. Brasília, 2022.
MINISTÉRIO DA SAÚDE. Nota Técnica nº 2/2022- SECOVID/GAB/SECOVID/MS: Vacinação não obrigatória de crianças de 05 a 11 anos contra Covid-19 durante a pandemia da Covid-19. Brasília, 2022.
Ethics approval and consent to participate
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Tavares, A.C.F.M.G., de Melo, A.K.G., Cruz, V.A. et al. Update to “guidelines on COVID-19 vaccination in patients with immune-mediated rheumatic diseases: a Brazilian Society of Rheumatology task force”. Adv Rheumatol 62, 29 (2022). https://doi.org/10.1186/s42358-022-00256-1