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  1. Many people with non-specific chronic low back pain (NSCLBP) do not recover with current conventional management. Systematic reviews show multidimensional treatment improves pain better than usual active inter...

    Authors: Sanaz Bemani, Javad Sarrafzadeh, Shohreh Noorizadeh Dehkordi, Saeed Talebian, Reza Salehi and Jamileh Zarei
    Citation: Advances in Rheumatology 2023 63:57
  2. Some studies have suggested the HLA-B27 gene may protect against some infections, as well as it could play a benefit role on the viral clearance, including hepatitis C and HIV. However, there is lack of SARS-C...

    Authors: GD Mota, CL Marques, SL Ribeiro, C Albuquerque, G Castro, D Fernandino, F Omura, A Ranzolin, G Resende, N Silva, M Souza, S Studart, R Xavier, M Yazbek and Marcelo M Pinheiro
    Citation: Advances in Rheumatology 2023 63:56
  3. Seasonal influenza A (H3N2) virus is an important cause of morbidity and mortality in the last 50 years in population that is greater than the impact of H1N1. Data assessing immunogenicity and safety of this v...

    Authors: Nadia Emi Aikawa, Eduardo Ferreira Borba, Verena Andrade Balbi, Adriana Maluf Elias Sallum, Izabel Mantovani Buscatti, Lucia Maria Arruda Campos, Kátia Tomie Kozu, Cristiana Couto Garcia, Artur Silva Vidal Capão, Adriana Coracini Tonacio de Proença, Elaine Pires Leon, Alberto José da Silva Duarte, Marta Heloisa Lopes, Clovis Artur Silva and Eloisa Bonfá
    Citation: Advances in Rheumatology 2023 63:55
  4. Previous studies have suggested that systemic metabolic abnormalities are closely related to psoriatic arthritis (PsA). Gamma-glutamyl transpeptidase (GGT) and indirect bilirubin (IBIL), two essential active s...

    Authors: Xu Wang, Yan Mao, Shang Ji, Huanrong Hu, Qian Li, Lichao Liu, Shaomin Shi and Yaling Liu
    Citation: Advances in Rheumatology 2023 63:53
  5. Cardiac involvement is one of the most serious complications of idiopathic inflammatory myopathy (IIM) that indicates poor prognosis. However, there is a lack of effective biomarkers for the identification of ...

    Authors: Hao Zhang, Huihui Chi, Liangzhe Xie, Yue Sun, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Qiongyi Hu, Jianfen Meng, Zhuochao Zhou, Jialin Teng, Chengde Yang and Yutong Su
    Citation: Advances in Rheumatology 2023 63:52
  6. The defect of B cell self-tolerance and the continuous antigen presentation by T cells (TCs) mediated by autoreactive B cells (BCs) play a key role in the occurrence and development of systemic lupus erythemat...

    Authors: Zhuobei Xie, Li Dai, Haohua He, Dengxiao Hong, Honghui Tang, Wenyan Xu, Zhongxin Chen, Hongtao Wang, Baiqing Li, Changhao Xie and Yuanyuan Wang
    Citation: Advances in Rheumatology 2023 63:51
  7. To compare the efficacy and safety between baricitinib (BARI) and tofacitinib (TOFA) for the treatment of the rheumatoid arthritis (RA) patients receiving methotrexate (MTX) in clinical practice.

    Authors: Xiaoling Liao, Wang Huo, Wen Zeng, Fang Qin, Fei Dong, Wanling Wei and Ling Lei
    Citation: Advances in Rheumatology 2023 63:50
  8. Behçet’s disease (BD) is a systemic vasculitis that can affect multiple systems, including the skin, mucous membranes, joints, eyes, gastrointestinal and nervous. However, the pathogenesis of BD remains unclea...

    Authors: Dan Hu and Jian-Long Guan
    Citation: Advances in Rheumatology 2023 63:49
  9. Juvenile Dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy in children. Imaging exams are useful for muscle assessment, with ultrasonography (US) being a promising tool in detecting dis...

    Authors: Renata Lopes Francisco de Andrade, José Alexandre Mendonça, Daniela Petry Piotto, Julio Brandão Guimarães and Maria Teresa Terreri
    Citation: Advances in Rheumatology 2023 63:48
  10. Psoriatic arthritis (PsA) is a chronic multisystem osteoarticular disease that requires specialized care. Most Brazilians depend on the public healthcare provided by the Unified Health System (Sistema Único de...

    Authors: Chayanne Natielle Rossetto, Penélope Esther Palominos, Natalia Pereira Machado, Eduardo dos Santos Paiva and Valderílio Feijó Azevedo
    Citation: Advances in Rheumatology 2023 63:47
  11. The study explored improvements in pulmonary inflammation and fibrosis in a bovine type II collagen-induced rheumatoid arthritis-associated interstitial lung disease mouse model after treatment with baricitini...

    Authors: Hongli Liu, Yan Yang, Jie Zhang and Xuelin Li
    Citation: Advances in Rheumatology 2023 63:45

    The Correction to this article has been published in Advances in Rheumatology 2023 63:46

  12. The extra-musculoskeletal manifestations (EMMs) such as recurrent acute anterior uveitis (rAAU), psoriasis (Ps), and inflammatory bowel disease (IBD), are related to the Spondyloarthritis (SpA), as well as the...

    Authors: Danielle dos Reis Annunciato, Thauana Luiza Oliveira, Vanessa Oliveira Magalhães and Marcelo de Medeiros Pinheiro
    Citation: Advances in Rheumatology 2023 63:44
  13. The p53 and p21 proteins are important regulators of cell cycle and apoptosis and may contribute to autoimmune diseases, such as systemic lupus erythematosus (SLE). As genetic polymorphisms may cause changes i...

    Authors: Jacyara Maria Brito Macedo, Amanda Lima Silva, Amanda Chaves Pinto, Leandro Ferreira Lopes Landeira, Elyzabeth Avvad Portari, Cintia Barros Santos-Rebouças and Evandro Mendes Klumb
    Citation: Advances in Rheumatology 2023 63:43
  14. The etiology of systemic lupus erythematosus is complex and incurable. A large number of systematic reviews have studied the risk factors of it. Mendelian randomization is an analytical method that uses geneti...

    Authors: Xin-Yu Xiao, Qian Chen, Yun-Zhou Shi, Li-Wen Li, Can Hua and Hui Zheng
    Citation: Advances in Rheumatology 2023 63:42
  15. Takayasu’s arteritis (TA) is a vasculitis that affects the aorta and its branches and causes stenosis, occlusion, and aneurysms. Up to 60% of TA patients are associated with cardiac involvement which confers a...

    Authors: Maria de Lourdes Castro de Oliveira Figueirôa, Maria Carolina Moura Costa, Maria Clara Moura Costa, Paulo Rocha Lobo, Leonardo Vinicius Sanches, Kátia Maria Alves Martins, Anna Paula Mota Duque Sousa, Ana Luisa Souza Pedreira and Mittermayer Barreto Santiago
    Citation: Advances in Rheumatology 2023 63:41
  16. Serum from systemic lupus erythematosus (SLE) patients has been shown to induce T-lymphocyte (TL) apoptosis. Given that different cells of the immune system display different sensitivity to apoptosis, we set t...

    Authors: Fernanda Vieira Mesquita, Vanessa Ferreira, Danilo Mesquita Jr and Luís Eduardo Coelho Andrade
    Citation: Advances in Rheumatology 2023 63:40
  17. The deposition of monosodium urate (MSU) crystals within synovial joints and tissues is the initiating factor for gout arthritis. Thus, MSU crystals are a vital tool for studying gout’s molecular mechanism in ...

    Authors: Fei Yan, Hui Zhang, Xuan Yuan, Xuefeng Wang, Maichao Li, Youlin Fan, Yuwei He, Zhaotong Jia, Lin Han and Zhen Liu
    Citation: Advances in Rheumatology 2023 63:39
  18. To determine prevalence and factors associated with flares post Coronavirus disease 2019 (COVID-19) mRNA vaccination in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and spondyloarthritis ...

    Authors: Warren Fong, Ting Hui Woon, Li-Ching Chew, Andrea Low, Annie Law, Yih Jia Poh, Siaw Ing Yeo, Ying Ying Leung, Margaret Ma, Amelia Santosa, Kok Ooi Kong, Chuanhui Xu, Gim Gee Teng, Anselm Mak, Sen Hee Tay, Tyng Yu Chuah…
    Citation: Advances in Rheumatology 2023 63:38
  19. The importance of proinflammatory T-cells and their cytokine production in patients with autoimmune arthritis has been widely described. Due to their immunomodulatory properties, mesenchymal stem cells (MSCs) ...

    Authors: Maximilian Riekert, Giovanni Almanzar, Marc Schmalzing, Norbert Schütze, Franz Jakob and Martina Prelog
    Citation: Advances in Rheumatology 2023 63:37
  20. Systemic inflammation, documented before rheumatoid arthritis (RA) diagnosis, is associated with accelerated atherosclerosis. We aimed to compare the prevalence of carotid plaque (CP) in RA patients in the fir...

    Authors: Dionicio Angel Galarza-Delgado, Jose Ramon Azpiri-Lopez, Natalia Guajardo-Jauregui, Jesus Alberto Cardenas-de la Garza, Andrea Nallely Garza-Cisneros, Alexis Garcia-Heredia, Mario Alberto Balderas-Palacios and Iris Jazmin Colunga-Pedraza
    Citation: Advances in Rheumatology 2023 63:36
  21. Takayasu arteritis (TAK) is a rare chronic granulomatous vasculitis that affects large vessels and usually begins in women of childbearing age, so it is not uncommon for pregnancies to occur in these patients....

    Authors: Marcela Ignacchiti Lacerda Ávila, Marcela Gaiotti Marques, Maria Eduarda Araújo Machado da Rocha, Flávia Cunha dos Santos, Manuella Lima Gomes Ochtrop, Nilson Ramires de Jesús, Guilherme Ribeiro Ramires de Jesús and Camila Souto Oliveira Elias
    Citation: Advances in Rheumatology 2023 63:35
  22. Although Rheumatoid Arthritis (RA) extra-articular manifestations (ExtRA) occurrence has been decreasing over time, they are still a major mortality risk factor for patients.

    Authors: Karina Rossi Bonfiglioli, Ana Cristina de Medeiros Ribeiro, Ana Paula Carnieletto, Ivânio Pereira, Diogo Souza Domiciano, Henrique Carriço da Silva, Alisson Pugliesi, Leticia Rocha Pereira, Maria Fernanda Resende Guimarães, Rina Dalva Neubarth Giorgi, Ana Paula Monteiro Gomides Reis, Claiton Viegas Brenol, Paulo Louzada-Júnior, Maria de Fátima Lobato da Cunha Sauma, Sebastião Cezar Radominski, Licia Maria Henrique da Mota…
    Citation: Advances in Rheumatology 2023 63:34
  23. Ankylosing Spondylitis (AS) patients face several challenges due to the nature of the disease and its physical and psychological complications. Sleep disorders are among the most important concerns. Sleep diso...

    Authors: Nader Salari, Narges Sadeghi, Amin Hosseinian-Far, Razie Hasheminezhad, Habibolah Khazaie, Shamarina Shohaimi and Masoud Mohammadi
    Citation: Advances in Rheumatology 2023 63:33
  24. Gout is a common inflammatory arthritis caused by increased serum uric acid levels. Untreated or insufficiently treated gout can lead to deposition of monosodium urate crystals in joints, cartilage, and kidney...

    Authors: Qiaoli Hua, Xusheng Liu, Yang Luo, Yujie Lin, Kairong Zheng, Ai Xia and Qianchun Yang
    Citation: Advances in Rheumatology 2023 63:32
  25. Our aim was to compare the efficacy of rituximab, tocilizumab, and abatacept in individuals with rheumatoid arthritis (RA) refractory to treatments with MTX or TNFi agents.

    Authors: Alisson Pugliesi, Amanda Borges de Oliveira, Ana Beatrice Oliveira, Ricardo Xavier, Licia Maria Henrique da Mota, Manoel Barros Bertolo, Miguel Angel Gonzalez-Gay, Gustavo Citera and Luiz Sergio Fernandes de Carvalho
    Citation: Advances in Rheumatology 2023 63:30
  26. Systemic lupus erythematosus (SLE) is a classic prototype of the multisystem autoimmune disease and follows a relapsing and remitting course. Triptolide is a diterpene triepoxide extracted from Chinese medicin...

    Authors: Xia Zhao, Wei Ji, Yan Lu, Weiwei Liu and Feng Guo
    Citation: Advances in Rheumatology 2023 63:29
  27. To investigate the clinical usefulness of serum superoxide dismutase (SOD) measurement in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

    Authors: Zhihuan Zhang, Wenhan Huang, Feifeng Ren, Lei Luo, Jun Zhou and Lin Tang
    Citation: Advances in Rheumatology 2023 63:28
  28. Previous studies has shown that nucleotide-binding and oligomerization domain-containing protein 2 (NOD2) is expressed in Fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis (RA) patients which is stim...

    Authors: Fereshteh Akbari-Papkiadehi, Ali Akbar Saboor-Yaraghi, Elham Farhadi, Mohammad Naghi Tahmasebi, Arash Sharafat Vaziri, Leila Aghaghazvini, Marzieh Asgari, Shiva Poursani, Fatemeh Mansouri, Ahmadreza Jamshidi and Mahdi Mahmoudi
    Citation: Advances in Rheumatology 2023 63:27
  29. Data on post-acute COVID-19 in autoimmune rheumatic diseases (ARD) are scarce, focusing on a single disease, with variable definitions of this condition and time of vaccination. The aim of this study was to ev...

    Authors: Clovis Artur Silva, Leonard de Vinci Kanda Kupa, Ana Cristina Medeiros-Ribeiro, Sandra Gofinet Pasoto, Carla Gonçalves Schahin Saad, Emily Figueiredo Neves Yuki, Joaquim Ivo Vasques Dantas Landim, Victor Hugo Ferreira e Léda, Luisa Sacchi de Camargo Correia, Artur Fonseca Sartori, Carolina Campagnoli Machado Freire Martins, Carolina Torres Ribeiro, Filipe Waridel, Victor Adriano de Oliveira Martins, Samuel Katsuyuki Shinjo, Danieli Castro Oliveira Andrade…
    Citation: Advances in Rheumatology 2023 63:26
  30. In patients with rheumatic diseases, the use of biological (b) or targeted synthetic (ts) disease-modifying antirheumatic drugs (DMARDs) after discontinuation of tumor necrosis factor inhibitors (TNFi) is know...

    Authors: Manuel Pombo-Suárez, Daniel Seoane-Mato, Federico Díaz-González, Fernando Sánchez-Alonso, Marta Sánchez-Jareño, Luis Cea-Calvo and Isabel Castrejón
    Citation: Advances in Rheumatology 2023 63:25
  31. The deficiency of ADA2 (DADA2) is a rare autoinflammatory disease provoked by mutations in the ADA2 gene inherited in a recessive fashion. Up to this moment there is no consensus for the treatment of DADA2 and...

    Authors: Adriana Melo, Luciana Martins de Carvalho, Virginia Paes Leme Ferriani, André Cavalcanti, Simone Appenzeller, Valéria Rossato Oliveira, Herberto Chong Neto, Nelson Augusto Rosário, Fabiano de Oliveira Poswar, Matheus Xavier Guimaraes, Cristina Maria Kokron, Rayana Elias Maia, Guilherme Diogo Silva, Gabriel Keller, Mauricio Domingues Ferreira, Dewton Moraes Vasconcelos…
    Citation: Advances in Rheumatology 2023 63:23
  32. Systemic sclerosis (SSc) is an immune-mediated rheumatic disease characterized by fibrosis and vascular lesions. Interstitial lung disease is an early complication of SSc and the main cause of death from SSc. ...

    Authors: Dandan Wang, Yimei Wei, Lulu Xu and Jie Zhang
    Citation: Advances in Rheumatology 2023 63:22
  33. Currently, only a few studies have described the general characteristics of patients with primary Sjögren’s syndrome (pSS) who tested negatives for anti-SSA and anti-SSB antibodies. We aimed to further investi...

    Authors: Jiaqi Chen, Qian He, Jianying Yang, TzuHua Wu, Ziwei Huang, Yan Zhang, Jiahe Liao, Lining Zhang, Xinbo Yu, Chuanhui Yao, Jing Luo and Qingwen Tao
    Citation: Advances in Rheumatology 2023 63:21
  34. Several studies have compared the clinical features and outcomes of late- and early-onset systemic lupus erythematosus (SLE) patients. However, these previous studies were uncontrolled. The current study aimed...

    Authors: Jarukit Mongkolchaiarunya, Antika Wongthanee, Nuntana Kasitanon and Worawit Louthrenoo
    Citation: Advances in Rheumatology 2023 63:20
  35. Microparticles (MPs) are membrane-derived vesicles released from cells undergoing activation or apoptosis with diverse proinflammatory and prothrombotic activities, that have been implicated in the pathogenesi...

    Authors: Sandra Maximiano de Oliveira, Ighor Luiz de Azevedo Teixeira, Carolina Nunes França, Maria Cristina de Oliveira Izar and Cristiane Kayser
    Citation: Advances in Rheumatology 2023 63:19
  36. Cognitive dysfunction (CD) is a widespread manifestation in adult systemic lupus erythematosus (SLE) patients, but this subject is rarely examined in patients with childhood-onset SLE (cSLE). This study aimed ...

    Authors: Flávia Patrícia Sena Teixeira Santos, Gilda Aparecida Ferreira, Jonas Jadim de Paula, Kalline Cristina Prata de Souza, Sandro Luiz Cançado Silva and Humberto Correa
    Citation: Advances in Rheumatology 2023 63:18
  37. Early rheumatoid arthritis (RA) offers an opportunity for better treatment outcomes. In real-life settings, grasping this opportunity might depend on access to specialized care. We evaluated the effects of ear...

    Authors: Cleandro Pires Albuquerque, Ana Paula Monteiro Gomides Reis, Ana Beatriz Vargas Santos, Manoel Barros Bértolo, Paulo Louzada Júnior, Rina Dalva Neubarth Giorgi, Sebastião Cezar Radominski, Maria Fernanda B. Resende Guimarães, Karina Rossi Bonfiglioli, Maria de Fátima L Cunha Sauma, Ivânio Alves Pereira, Claiton Viegas Brenol, Licia Maria Henrique Mota, Leopoldo Santos-Neto and Geraldo Rocha Castelar Pinheiro
    Citation: Advances in Rheumatology 2023 63:17
  38. The prevalence of HLA-B27 gene positivity in healthy Caucasian communities varies between 8 and 14%. However, there is a lack of information in countries with a high rate of miscegenation, such as Brazil.

    Authors: Gustavo Gomes Resende, Carla Gonçalves Schahin Saad, Danielli Cristina Muniz de Oliveira, Julio Silvio de Sousa Bueno Filho, Percival Degrava Sampaio-Barros and Marcelo de Medeiros Pinheiro
    Citation: Advances in Rheumatology 2023 63:16
  39. Secukinumab has shown high efficacy in randomized controlled trials in both ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Here, we investigated its real-life effectiveness and tolerability in a co...

    Authors: Francesco Molica Colella, Gaetano Zizzo, Vincenzo Parrino, Maria Teresa Filosa, Riccardo Cavaliere, Francesco Fazio, Aldo Biagio Molica Colella and Antonino Mazzone
    Citation: Advances in Rheumatology 2023 63:15
  40. Rheumatoid arthritis is an autoimmune inflammatory disease that often leads patients to muscle impairment and physical disability. This study aimed to evaluate changes in the activity of proteasome system in s...

    Authors: Vivian Oliveira Nunes Teixeira, Bárbara Jonson Bartikoski, Rafaela Cavalheiro do Espirito Santo, Paulo Vinícius Gil Alabarse, Khetam Ghannan, Jordana Miranda Souza Silva, Lidiane Isabel Filippin, Fernanda Visioli, Lorena Martinez-Gamboa, Eugen Feist and Ricardo Machado Xavier
    Citation: Advances in Rheumatology 2023 63:14
  41. In chronic arthropathies, there are several mechanisms of joint destruction. In recent years, studies have reported the implication of receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprote...

    Authors: Thaíse Oliveira Quaresma, Sérgio Couto Luna de Almeida, Tarcília Aparecida da Silva, Paulo Louzada-Júnior and Renê Donizeti Ribeiro de Oliveira
    Citation: Advances in Rheumatology 2023 63:13
  42. Clinical practice guidelines (CPG) are developed to align standards of health care around the world, aiming to reduce the incidence of misconducts and enabling more effective use of health resources. Consideri...

    Authors: Ana Karla Guedes de Melo, Ana Luíza Mendes Amorim Caparroz, Mirhelen Mendes de Abreu, Daniela Castelo Azevedo, Leonardo Santos Hoff, Sérgio Candido Kowalski, Themis Mizerkowski Torres, Solange Murta Barros, Gilda Aparecida Ferreira, Odirlei André Montecielo, Ricardo Machado Xavier and Virgínia Fernandes Moça Trevisani
    Citation: Advances in Rheumatology 2023 63:12
  43. Diagnosis of SS is a complex task, as no symptom or test is unique to this syndrome. The American-European Consensus Group (AECG 2002) and the American-European classification criteria of 2016 (ACR/EULAR 2016)...

    Authors: Ana Paula Espíndula Gianordoli, Rafaella Vila Real Barbosa Laguardia, Maria Carmen F. S. Santos, Fabiano Cade Jorge, Amanda da Silva Salomão, Larissa Carvalho Caser, Isac Ribeiro Moulaz, Érica Vieira Serrano, Samira Tatiyama Miyamoto, Ketty Lysie Libardi Lira Machado and Valéria Valim
    Citation: Advances in Rheumatology 2023 63:11
  44. BDNF has been implicated in the pathophysiology of systemic lupus erythematosus (SLE), especially its neuropsychiatric symptoms. The purpose of this study was to investigate the profile of blood BDNF levels in...

    Authors: Parnian Shobeiri, Saba Maleki, Mobina Amanollahi, Amirhossein Habibzadeh, Antonio L. Teixeira and Nima Rezaei
    Citation: Advances in Rheumatology 2023 63:8

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