The prevalence of peripheral neuropathy was 48.5%, in agreement with the literature, which presents results between 17 and 72.2% depending on the methodology and the local of assessment if in upper, lower limbs or both [13,14,15,16, 26].
The findings regarding the type of neural involvement are similar to the studies by Lanzillo et al. [27], Nadkar et al. [28], Bayrak et al. [13] and Sim et al. [2] in which there is a predominance of the sensorimotor pattern; however, they differ from Biswas et al. [26] and Agarwal et al. [29], who found a slight predominance of the sensory pattern in relation to the sensorimotor.
Regarding the type of neuronal lesion, the findings of the present study are like those in the literature in which there is a clear predominance of axonal type lesions, although it is difficult to compare due to differences in the methods of ENMG assessment [13, 14, 26, 27, 29].
There was no association between age, gender and peripheral neuropathy as well as in several previous reports [13, 15, 28], only the study by Sim et al. [2] found an association between age and peripheral neuropathy.
Most of the sample was women above 50 years old, which was also found in most studies due to two to three times higher prevalence of RA in females and common age of presentation starting from the fourth decade of life [30]. Although advanced, the age range was below the age in which alterations of the peripheral nerves are known to be detected, which is from 80 years on [31].
No previous study had investigated the association between neuropathy in patients with RA and the occurrence of falls. However, we did not find in our study a significant correlation between peripheral neuropathy and falls.
There was no significant association between neuropathy and disease activity indices which was also reported by Biswas et al. [26], Agarwal et al. [29] and Li et al. [32], different however from the results of Bayrak et al. [13] and Umay et al. [14], revealing that this is still a risk factor to be studied regarding neuropathy in patients with RA.
In the present study no association was found between peripheral neuropathy and functionality as well as in the studies by Agarwal et al. [29], Sim et al. [2] and Umay et al. [14], only the study by Bayrak et al. [13] found significant relationship between neuropathy and HAQ scores.
There was a significant association between peripheral neuropathy and balance disorders, which corroborates our hypothesis that neuropathy may contribute to the risk of falls, although it is not possible to establish a causal relationship in this type of study. The association between altered sural nerve sensation and balance disorder (P = 0.034) could also corroborate this hypothesis.
As expected, it was also observed association of neuropathic pain with peripheral neuropathy (P = 0.016) and neuropathy was found in 72.2% of patients with neuropathic pain as well as in the study of Filatova and Erdes [33] who found it in 96%.
Reduced cutaneous sensitivity in the fibular nerve was significantly associated to peripheral neuropathy as with Souza et al. [24] who demonstrated in patients with diabetes a good correlation between the severity of neuropathy assessed by monofilament examination and the ENMG exam. These findings help to support the hypothesis that the noninvasive monofilament test may be useful in the evaluation of peripheral neuropathy in patients with RA.
The absence of deep reflexes showed significant relation with peripheral neuropathy as well as in the studies of Good et al. [12] and Agarwal et al. [29], which was not confirmed by Yanshan et al. [32].
No other study was found on the relationship between peripheral neuropathy and fear of falling. In the present study, fear of falling was significantly associated with peripheral neuropathy (P = 0.001), suggesting that reduced muscle strength and altered sensitivity may increase walking instability and fear of falling.
Age in this study, showed a surprisingly negative correlation with the number of falls in the previous 12 months (r = − 0.375, P = 0.032) different from that found in the general population in which age is an important risk factor [7, 34]. Studies in RA found no relationship between age and falls [4, 33, 35]. We found a small negative association between age and falls, but the lower mobility of the older patients could be associated to a lower occurrence of falls. In the 6 months following the assessment, there was no association between the number of falls and age (R = − 0.340, P = 0.053).
The incidence of falls in the present study was 51.5% in retrospective analysis and 33.3% in 6-month prospective analysis agreeing with the literature that presents incidence from 10 to 54%, including two recent studies published 2019 and 2020 that found incidence of 52.2% and 51% respectively [36, 37].
Most of the falls, in both retrospective (55.7%) and prospective (66.7%) analysis occurred at home similarly to the study of Stanmore et al. (68.5%), Lourenço, Roma, and Assis [18], and Lourenço, Carli, and Assis [20]. It is likely that similarly to the elderly [7, 38], a combination of functional impairment and fear of falling reduces the patient's mobility to other environments, increasing the time staying at home where the environment is more familiar and safer.
Fear of falling was associated to the retrospective assessment of falls, as seen by Stanmore et al. [39] and Gaino et al. [36], but not in the prospective one as most of the studies [6, 35, 40, 41]. Few patients presented repeated falls in the retrospective and prospective assessments and that could be related to the post-fall syndrome in which a reduction of overall mobility and daily activities is observed after the first fall [42].
In the present sample there was a significant positive association between BMI and the occurrence of falls, both in the retrospective and prospective evaluation, although most of the studies have not found association [36, 41, 43], the largest cohort in the study by Furuya [44], confirmed our finding.
Most falls did not lead to serious consequences. In the 12 months prior to the assessment 17.6% of the group who fell had fractures, and 9.1% in the prospective evaluation, which agrees with the findings of most studies that have found a range between 5 and 18,3% [6, 43,44,45,46,47].
Most patients reported some type of lower limb pain, being 40.7% classified as neuropathic pain, but no association was found between the risk of falls or any type of pain, in retrospective and prospective evaluation, as in other studies [37, 44, 45]. Pain intensity measured by the visual analogue scale showed a positive relationship with falls in some studies [35, 45] but this data was not evaluated in our study.
We found an association between worse balance and neuropathic pain (R = 0.450, P = 0.018), but we did not find other similar study in patients with RA.
In the present study, patients with worse balance also had worse functionality. Assessment of balance and functionality in patients with RA was found only in the study by Aydog et al. [48] who assessed dynamic balance using the Biodex Stability System platform but found no differences in HAQ between patients who completed and those who failed to complete the test. Balance was also related to measures of disease activity DAS-28ESR, DAS-28CRP and CDAI as well as in a previous study performed in our outpatient clinic and in the study by Bohler et al. [6, 49].
Association between balance and disease activity was not confirmed in The study by Dimachkie et al. [50] that used 4-m walk test and the study by Aydog et al. [48] that used dynamic platform balance test.
We found a medication use median of 6, higher than severe polypharmacy criterion proposed by Kusano [51], however, there was no relationship between the number of medications in use and the risk of falls in both retrospective and prospective evaluation, differing from the studies of Stanmore et al. [45] and Armstrong et al. [52].
Regarding use of antihypertensive drugs and the risk of falling the odds ratio observed were 7 in the present study, 9 in the study by Hayashibara et al. [43] and 2.82 in the study by Mikos et al. [37]. The mechanism to the risk increment risk in patients with RA is not known, but in elderly orthostatic hypotension has been suggested [53]. There was no elevation in the risk of falls in the prospective assessment.
The use of benzodiazepines and antidepressants that are often associated with the risk of falls in the elderly and in RA [7, 52] was not related to the number of falls in the present study, which may have been due to the small number of patients using these medications.
The duration of the disease had no correlation with the number of falls, as in several other studies [30, 35, 41].
Disease activity measures showed a sample with a predominance of disease in activity, with no correlation between this indexes and the number of falls evaluated retrospectively or prospectively, which agrees with several studies [30, 43, 44], but was not confirmed in other studies [36, 45, 49]. This shows that disease activity is still a risk factor to be studied in relation to falls in RA.
The functionality assessment showed a sample with mild disability and was not related to the number of falls in retrospective and prospective evaluation, as in several previous studies [35, 41, 43, 52]. Some recent studies found association, including Oh et al. [54] that evaluated a large cohort with 3469 patients [37].
We found no relationship between falls and altered balance in both retrospective and prospective evaluation, which is a controversial finding among studies even though the tests used to assess balance vary among them. The study by Lourenço, Roma, and Assis [6] showed moderate to strong correlation between SPPB and other balance tests such as the Berg Balance Scale and the Timed Up and Go Test. Kawabata et al. [55] in a study evaluating balance in patients with RA found no differences in SPPB between fallers and non-fallers, however there was a difference when only the 5-repetition chair stand test was used, suggesting that the scores in performance and/or balance could compensate the lower values of muscle strength. These findings are in line with our results, which showed longer times in the 5-repetition chair stand test in patients with any type of motor neuropathy, suggesting that motor impairment could be more important in increasing the risk of falls in patients with RA. Other finding that corroborates this hypothesis is that the major cause of falls in our sample was tripping, which can be explained by the motor impairment caused by the neuropathy leading to diminished foot dorsiflexion and hip flexion, impairments that are commonly associated to an increase in the trip related fall risk [56].
One limitation of our study is the small size of the sample, caused by the recruitment difficulties imposed by the COVID-19 pandemics, so we believe a study with bigger sample could help to find associations we did not find. Prospective studies with a control group could also help to stablish causal relation between neuropathy and the other outcomes, and studies comparing a group with intervention in muscle strength of lower limbs, with a control group, could also corroborate our finding that the motor impairment caused by the neuropathy could increase the risk of falls.
Another limitation of our study was not excluding patients diagnosed with diabetes, which is known to be the main condition associated with peripheral neuropathy [24]. This choice was made to maintain a larger sample size with better external validity, since diabetes is commonly found among patients with RA with incidence ranging between 9.2% and 20.7%, as demonstrated by a recent systematic review [57]. It must be considered that the peripheral nerve involvement caused by RA or diabetes are similar, since Good et al. [12] observed no differences in the electrophysiological study in RA in patients with and without diabetes.
The relevance of this study is evaluating, for the first time, the relationship between peripheral
neuropathy, balance and falls in patients with RA. However, no association was found and the occurrence of falls in this group of patients still needs a better determination of risk factors and predictors.