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  1. Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality...

    Authors: Karina Rossi Bonfiglioli, Licia Maria Henrique da Mota, Ana Cristina de Medeiros Ribeiro, Adriana Maria Kakehasi, Ieda Maria Magalhães Laurindo, Rina Dalva Neubarth Giorgi, Angela Luzia Branco Pinto Duarte, Ana Paula Monteiro Gomides Reis, Mariana Peixoto Guimarães Ubirajara e Silva de Souza, Claiton Viegas Brenol, Geraldo da Rocha Castelar Pinheiro, Cleandro Pires de Albuquerque, Charlles Heldan de Moura Castro, Gustavo Luiz Behrens Pinto, Jose Fernando Verztman, Luciana Feitosa Muniz…

    Citation: Advances in Rheumatology 2021 61:70

    Content type: Position article and guidelines

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  2. Psoriatic arthritis (PsA) is a chronic and systemic immune disease characterized by inflammation of peripheral and/or axial joints and entheses in patients with psoriasis (PsO). Extra-articular and extracutane...

    Authors: Sueli Carneiro, Penelope Esther Palominos, Sônia Maria Alvarenga Anti, Rodrigo Luppino Assad, Rafaela Silva Guimarães Gonçalves, Adriano Chiereghin, Andre Marun Lyrio, Antônio Carlos Ximenes, Carla Gonçalves Saad, Célio Roberto Gonçalves, Charles Lubianca Kohem, Cláudia Diniz Lopes Marques, Cláudia Goldenstein Schainberg, Eduardo de Souza Meirelles, Gustavo Gomes Resende, Lenise Brandao Pieruccetti…

    Citation: Advances in Rheumatology 2021 61:69

    Content type: Review

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  3. Assessing disease activity in rheumatoid arthritis (RA) patients requires comprehensive quantification of tender and swollen joints. We aimed to evaluate the correlation and agreement between rheumatologists a...

    Authors: Gerardo Quintana-López, Kevin Maldonado-Cañón, Jorge Bruce Flórez-Suárez, Paul Méndez-Patarroyo, Paola Coral-Alvarado and Enrique Calvo

    Citation: Advances in Rheumatology 2021 61:68

    Content type: Research

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  4. This study aimed to investigate the relationship between the neuropathic pain in knee osteoarthritis with the body composition, anthropometric and postural features, physical function, and quality of life.

    Authors: Uğur Güngör Demir, Ali Nail Demir and Naciye Füsun Toraman

    Citation: Advances in Rheumatology 2021 61:67

    Content type: Research

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  5. Diet plays a critical role in Systemic Lupus Erythematosus (SLE) patients, impacting on the microbiota composition and, consequently, on the immune response. The objective was to analyze and verify the diet ef...

    Authors: Aline Mizusaki Imoto, Leila Bernarda Gottems, Ana Lúcia Salomon, Helbert Eustáquio Cardoso e Silva, Império Lombardi Júnior, Maria Stella Peccin, Fábio Ferreira Amorim and Levy Aniceto Santana

    Citation: Advances in Rheumatology 2021 61:66

    Content type: Review

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  6. The management of anxiety and depression symptoms in rheumatoid arthritis (RA) patients is vital. Previous study findings on this topic are conflicting, and the topic remains to be thoroughly investigated. Thi...

    Authors: Miyabi Uda, Motomu Hashimoto, Ryuji Uozumi, Mie Torii, Takao Fujii, Masao Tanaka, Moritoshi Furu, Hiromu Ito, Chikashi Terao, Wataru Yamamoto, Genichi Sugihara, Yukako Nakagami, Tsuneyo Mimori and Kazuko Nin

    Citation: Advances in Rheumatology 2021 61:65

    Content type: Research

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  7. Antiphospholipid syndrome (APS) is characterized by episodes of thrombosis, obstetric morbidity or both, associated with persistently positive antiphospholipid antibodies (aPL). Studying the profile of a rare ...

    Authors: Erivelton de Azevedo Lopes, Gustavo Guimarães Moreira Balbi, Maria G. Tektonidou, Vittorio Pengo, Savino Sciascia, Amaia Ugarte, H. Michael Belmont, Maria Gerosa, Paul R. Fortin, Chary Lopez-Pedrera, Lanlan Ji, Hannah Cohen, Guilherme Ramires de Jesús, D. Ware Branch, Cecilia Nalli, Michelle Petri…

    Citation: Advances in Rheumatology 2021 61:64

    Content type: Research

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  8. The objective of this randomized controlled trial (RCT) was to investigate the effectiveness of the lower limb rehabilitation protocol (LLRP) combined with mobile health (mHealth) applications on knee pain, mo...

    Authors: Muhammad Tariq Rafiq, Mohamad Shariff Abdul Hamid and Eliza Hafiz

    Citation: Advances in Rheumatology 2021 61:63

    Content type: Research

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  9. The knee osteoarthritis (OA) is a joint disease characterized by degradation of articular cartilage that leads to chronic inflammation. Exercise programs and photobiomodulation (PBM) are capable of modulating ...

    Authors: Patricia Gabrielli Vassão, Ana Carolina Flygare de Souza, Raquel Munhoz da Silveira Campos, Livia Assis Garcia, Helga Tatiana Tucci and Ana Claudia Muniz Renno

    Citation: Advances in Rheumatology 2021 61:62

    Content type: Research

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  10. Osteoarthritis is the most common form of hand arthritis and arthritis of the carpometacarpal joint of the thumb is a potentially limiting disease. There is no homogeneity in the evaluation of outcomes for the...

    Authors: Vinícius Alexandre de Souza Almeida, Carlos Henrique Fernandes, Lia Miyamoto Meireles, Flavio Faloppa, Benno Ejnisman and Moises Cohen

    Citation: Advances in Rheumatology 2021 61:61

    Content type: Research

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  11. There is a lack of information on the role of chronic use of hydroxychloroquine during the SARS-CoV-2 outbreak. Our aim was to compare the occurrence of COVID-19 between rheumatic disease patients on hydroxych...

    Authors: Gecilmara Salviato Pileggi, Gilda Aparecida Ferreira, Ana Paula Monteiro Gomides Reis, Edgard Torres Reis-Neto, Mirhelen Mendes Abreu, Cleandro Pires Albuquerque, Nafice Costa Araújo, Ana Beatriz Bacchiega, Dante Valdetaro Bianchi, Blanca Bica, Eloisa Duarte Bonfa, Eduardo Ferreira Borba, Danielle Christinne Soares Egypto Brito, Ângela Luzia Branco Pinto Duarte, Rafaela Cavalheiro Espírito Santo, Paula Reale Fernandes…

    Citation: Advances in Rheumatology 2021 61:60

    Content type: Research

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  12. Fibromyalgia syndrome (FMS) is both a challenging and disabling condition. The International Association for the Study of Pain (IASP) classifies FMS as chronic primary pain, and it can negatively impact indivi...

    Authors: Marina Carvalho Arruda Barreto, Fabianna Resende Jesus Moraleida, Cristiane Vitaliano Graminha, Camila Ferreira Leite, Shamyr Sulyvan Castro and Ana Carla Lima Nunes

    Citation: Advances in Rheumatology 2021 61:58

    Content type: Research

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  13. Depression is a quite common comorbidity in patients with rheumatoid arthritis (RA) and is thought to influence its severity. This study aims to estimate, in a large cohort of Italian patients with RA, the pre...

    Authors: Sara Pezzato, Chiara Bonetto, Cristian Caimmi, Simona Tomassi, Ilaria Montanari, Maria Giulia Gnatta, Elena Fracassi, Doriana Cristofalo, Maurizio Rossini, Antonio Carletto and Sarah Tosato

    Citation: Advances in Rheumatology 2021 61:57

    Content type: Research

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  14. Determining potential predictors of clinical response would allow a more personalized rheumatoid arthritis (RA) treatment approach in heterogeneous populations such as Latin American (LA) patients.

    Authors: Maria de la Vega, Generoso Guerra Bautista, Ricardo Machado Xavier, César Pacheco-Tena, Gastón Solano, Ronald D. Pedersen, Annette Eva Szumski, Cecilia Borlenghi, Karina Santana and Bonnie Vlahos

    Citation: Advances in Rheumatology 2021 61:56

    Content type: Research

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  15. Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs. Women with SS often experience gynecological symptoms due to the disease and ...

    Authors: Fabiola Reis Oliveira, Valeria Valim, Sandra Gofinet Pasoto, Marilena Leal Mesquita Silvestre Fernandes, Maria Lucia Lemos Lopes, Sonia Cristina de Magalhães Souza Fialho, Aysa César Pinheiro, Laura Caldas dos Santos, Simone Appenzeller, Tania Fidelix, Sandra Lucia Euzébio Ribeiro, Danielle Christinne Soares Egypto de Brito, Tatiana Libório, Maria Carmen Lopes Ferreira Silva Santos, Leandro Tanure, Juliana DAgostino Gennari…

    Citation: Advances in Rheumatology 2021 61:54

    Content type: Position article and guidelines

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  16. The aim of the study was to assess gait pattern of patients diagnosed with fibromyalgia (FM) while performing demanding motor and/or cognitive dual tasks while walking. Further, idea was to explore possible co...

    Authors: Goran Radunović, Zoran Veličković, Melanija Rašić, Saša Janjić, Vladana Marković and Saša Radovanović

    Citation: Advances in Rheumatology 2021 61:53

    Content type: Research

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  17. Clinically evident interstitial lung disease (ILD) affects between 10 and 42% of the patients with rheumatoid arthritis (RA). Airway involvement seems to be even more common. Most of the available evidence com...

    Authors: Francisco Paulin, Anastasia Secco, Federico Benavidez, Juan José Rodríguez Moncalvo, Orlando Gabriel Carballo, Fernanda Ingenito, Martin Eduardo Fernández, Agustina Cáceres, Fabian Caro, Patricia Sasaki, María Laura Alberti, Paola Orausclio, Augusto Riopedre, Santiago Rossi and María Celina de la Vega

    Citation: Advances in Rheumatology 2021 61:52

    Content type: Research

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  18. The ACR/EULAR recommendations endorse the use of glucocorticoids (GCs) for rheumatoid arthritis (RA) patients’ flares and as a bridge to a DMARD. However, the recommendation of low dose short-term monotherapy ...

    Authors: John M. Stacy, Jacob R. Greenmyer, James R. Beal, Abe E. Sahmoun and Erdal Diri

    Citation: Advances in Rheumatology 2021 61:50

    Content type: Research

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  19. Nail psoriasis occurs frequently in patients with psoriatic disease, it can lead to functional impairment, pain, discomfort, decreased quality of life and can also be a predictor for the development of arthrit...

    Authors: Samanta Daiana De Rossi, José Alexandre Mendonça, Penelope Ester Palominos, Charles Lubianca Kohem, Tania Ferreira Cestari and Rafael Mendonça da Silva Chakr

    Citation: Advances in Rheumatology 2021 61:48

    Content type: Research

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  20. To evaluate the quality of referrals for a first Rheumatology consultation at a tertiary care center in a southern Brazilian capital (Porto Alegre, RS), having as background findings from a similar survey perf...

    Authors: Deise Marcela Piovesan, Vanessa Barrili Busato, Romulo Gomes da Silveira, Aline Defaveri do Prado, Cynthia Goulart Molina-Bastos, Sheila Hickmann, Guilherme Kopik Bongiorno, Camila de David Cruz, Sheron Zamboni, Julio César Simon, Marcelo Rodrigues Gonçalves and Markus Bredemeier

    Citation: Advances in Rheumatology 2021 61:47

    Content type: Research

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  21. Infections are a major cause of morbidity and mortality in systemic lupus (SLE). Vaccination would be an effective method to reduce infection rate. Coverage for influenza and pneumococcus appears to be low in ...

    Authors: Edson Hernán Chiganer, Bruno Camargo Ochi and Carmen Flora Lessa

    Citation: Advances in Rheumatology 2021 61:46

    Content type: Research

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  22. As the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread rapidly, there are still many unresolved questions of how this vir...

    Authors: Piero Ruscitti, Alessandro Conforti, Paola Cipriani, Roberto Giacomelli, Marco Tasso, Luisa Costa and Francesco Caso

    Citation: Advances in Rheumatology 2021 61:45

    Content type: Review

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  23. The protein chitinase-3-like-1 (YKL-40) is rarely analyzed in patients with myositis. Therefore, we aimed to evaluate YKL-40 serum levels; correlate them with laboratory and clinical parameters, disease status...

    Authors: Renata Casseb de Souza Carboni, Gustavo Luiz Behrens Pinto and Samuel Katsuyuki Shinjo

    Citation: Advances in Rheumatology 2021 61:44

    Content type: Research

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  24. Systemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by being multi-systemic and, therefore, reaching various organs and affecting mainly young women. Its pathogenesis comprehends many fa...

    Authors: Juliana Rosa Pires Vieira, Andréa Toledo de Oliveira Rezende, Marcos Rassi Fernandes and Nilzio Antonio da Silva

    Citation: Advances in Rheumatology 2021 61:42

    Content type: Research

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  25. During the COVID-19 pandemic, individuals faced psychological stress caused by fear and anxiety due to the high transmission and mortality rate of the disease, the social isolation, economic problems, and diff...

    Authors: Damla Cankurtaran, Nihal Tezel, Buse Ercan, Sadik Yigit Yildiz and Ece Unlu Akyuz

    Citation: Advances in Rheumatology 2021 61:41

    Content type: Research

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  26. Juvenile idiopathic arthritis (JIA) can cause reduced exercise capacity, deterioration in functional activities, and poor health-related quality of life. This study aims to objectively reveal lower extremity i...

    Authors: Sevtap Acer Kasman, Özgür Zeliha Karaahmet, Ajda Bal Hastürk, Özge Başaran, Banu Çelikel Acar, Halise Hande Gezer and Aytül Çakcı

    Citation: Advances in Rheumatology 2021 61:39

    Content type: Research

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  27. Rheumatoid arthritis (RA) is a common autoimmune systemic inflammatory disease. In addition to joint involvement, RA patients frequently have other comorbidities, such as cardiovascular diseases. Drugs used fo...

    Authors: Gustavo Nogueira Schincariol Vicente, Ivânio Alves Pereira, Gláucio Ricardo Werner de Castro, Licia Maria Henrique da Mota, Ana Paula Carnieletto, Dhara Giovanna Santin de Souza, Fabiana Oenning da Gama, Ana Beatriz Vargas Santos, Cleandro Pires de Albuquerque, Manoel Barros Bértolo, Paulo Louzada Júnior, Rina Dalva Neubarth Giorgi, Sebastião Cezar Radominski, Maria Fernanda Brandão Resende Guimarães, Karina Rossi Bonfiglioli, Maria de Fátima Lobato da Cunha Sauma…

    Citation: Advances in Rheumatology 2021 61:38

    Content type: Research

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  28. To investigate the diagnostic performance of single-source dual-energy computed tomography (DECT) based on gemstone spectral imaging technology (including Discovery CT750HD and Revolution CT) in patients with ...

    Authors: Jin Shang, Xiao-Hu Li, Shu-Qin Lu, Yi Shang, Lu-Lu Li and Bin Liu

    Citation: Advances in Rheumatology 2021 61:36

    Content type: Research

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  29. Trunk pelvic dissociation is fundamental to the compensatory mechanism for muscle weakness during body bending. We carried out an early investigation of gait changes in a sample of community-dwelling women ≥60...

    Authors: Leda Magalhaes Oliveira, Suely Roizenblatt, Flavio Duarte Silva, Arnaldo Roizenblatt, Artur Rocha Correa Fernandes and Vera Lucia Szejnfeld

    Citation: Advances in Rheumatology 2021 61:35

    Content type: Research

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  30. Systemic sclerosis (SSc) is a chronic disease characterized by autoimmunity, vasculopathy, and visceral and cutaneous fibrosis. Vitamin D has several functions in the immunological system, and different studie...

    Authors: Laiana Schneider, Vanessa Hax, Odirlei Monticielo, Tamires Ferri Macedo, Roberta Kern Menna Barreto, Natália Aydos Marcondes and Rafael Chakr

    Citation: Advances in Rheumatology 2021 61:34

    Content type: Research

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  31. Vasculitis damage index (VDI) is a validated damage index for systemic vasculitis, and as Behçet’s disease is considered one of systemic vascular disease we aimed to study the relationship of the vasculitis da...

    Authors: Fatema T. Elgengehy, Sherif M. Gamal, Nesreen Sobhy, Ibrahem Siam, Ahmed M. Soliman, Ghada W. Elhady and Tamer A. Gheita

    Citation: Advances in Rheumatology 2021 61:33

    Content type: Research

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  32. To evaluate the perception of rheumatologists regarding the recommendations of the Brazilian Consensus for detection of Autoantibodies (BCA) on HEp-2 Cells by Indirect Immunofluorescence assay (IFA) and how BC...

    Authors: Isadora Carvalho Medeiros Francescantonio, Leandro Augusto Rodrigues dos Santos, Paulo Luiz Carvalho Francescantonio, Luiz Eduardo Coelho Andrade and Wilson de Melo Cruvinel

    Citation: Advances in Rheumatology 2021 61:32

    Content type: Research

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  33. Osteoarthritis (OA) is defined as a degenerative disease. Pivotal roles of long non-coding RNA (lncRNAs) in OA are widely elucidated. Herein, we intend to explore the function and molecular mechanism of lncRNA...

    Authors: Binfeng Wang and Xiangwei Liu

    Citation: Advances in Rheumatology 2021 61:31

    Content type: Research

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  34. The Functional Index for Hand Osteoarthritis (FIHOA) is a simple, reliable, and reproducible specific instrument to evaluate hand OA that can be applied both in clinical practice and research protocols. In ord...

    Authors: Francisco Vileimar Andrade de Azevedo, Hermano Alexandre Lima Rocha, Anamaria Jones, Jamil Natour and Francisco Airton Castro da Rocha

    Citation: Advances in Rheumatology 2021 61:30

    Content type: Research

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    The Correction to this article has been published in Advances in Rheumatology 2021 61:37

  35. Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent episodes of fever and serositis. Sacroiliitis can be observed in some FMF patients. This study aimed to compare the ...

    Authors: Hülya Kaçmaz, Esin Aldemir, Ayşe Tanatar, Şerife Gül Karadağ, Mustafa Çakan, Hafize Emine Sönmez and Nuray Aktay Ayaz

    Citation: Advances in Rheumatology 2021 61:29

    Content type: Research

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  36. Few studies have evaluated the relation of quality of life (QoL) with symptoms and disease activity in primary Sjögren’s syndrome (pSS). There is also scant information on the predictors of QoL in this populat...

    Authors: Laiza Hombre Dias, Samira Tatiyama Miyamoto, Raquel Altoé Giovelli, Caerê Iamonde Maciel de Magalhães and Valeria Valim

    Citation: Advances in Rheumatology 2021 61:28

    Content type: Research

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  37. Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by vasculopathy and fibrosis, which can be subclassified into diffuse cutaneous (dSSc) and limited cutaneous (lSSc) subtypes. Previous stu...

    Authors: Laiana Schneider, Natália Aydos Marcondes, Vanessa Hax, Isadora Flesch da Silva Moreira, Carolina Yuka Ueda, Rafaella Romeiro Piovesan, Ricardo Xavier and Rafael Chakr

    Citation: Advances in Rheumatology 2021 61:27

    Content type: Research

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  38. The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is a potential biomarker of vulnerability to pain. Thus, the present study aimed to investigate the association of this polymorphi...

    Authors: Angela Shiratsu Yamada, Flavia Tasmim Techera Antunes, Camila Ferraz, Alessandra Hubner de Souza and Daniel Simon

    Citation: Advances in Rheumatology 2021 61:24

    Content type: Research

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  39. Chronic prostatitis has been a common disease reported with high frequency in ankylosing spondylitis (AS) even from decades ago. Infectious (Chlamydia trachomatis) or non-infectious (uric acid) prostatitis can hy...

    Authors: Eduardo Deves, Rodrigo Novotny, Fernando Hartmann Barazzetti, Mara Cristina Scheffer, Letícia Kramer Pacheco, Adriana Fontes Zimmermann, Ivânio Alves Pereira, Maria Luiza Bazzo and Fabricio Souza Neves

    Citation: Advances in Rheumatology 2021 61:23

    Content type: Research

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  40. Hepatitis B virus (HBV) reactivation consequent to immunosuppressive therapy is an increasingly prevalent problem with serious clinical implications. Treatment with biologic agents conduces to the loss of prot...

    Authors: Ming-Hui Hung, Ya-Chih Tien and Ying-Ming Chiu

    Citation: Advances in Rheumatology 2021 61:22

    Content type: Research

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