Effects of intra-articular injection of platelet-rich plasma on the inflammatory process and histopathological characteristics of cartilage and synovium in animals with osteoarthritis: a systematic review with meta-analysis

Table 3 SYRCLE’s Rob toll criteria for quality assessment

Author	Year	Selection			Performance		Detection		Attrition	Reporting	Other	Yes items
Author	Year	1	2	3	4	5	6	7	8	9	10	Yes items
Ahmad et al.	2020	Unclear	No	Unclear	Unclear	No	No	No	Unclear	Yes	Unclear	1/10
Almasry et al.	2014	Unclear	No	Unclear	Unclear	No	No	Yes	Yes	Yes	Unclear	3/10
Arican et al.	2018	Unclear	No	Unclear	No	Unclear	No	Unclear	Unclear	Yes	Unclear	1/10
Asjid et al.	2018	No	No	No	Unclear	No	No	No	Unclear	Yes	Unclear	1/10
Chouhan et al.	2019	Unclear	Yes	No	No	No	No	No	Unclear	Yes	Unclear	2/10
Coskun et al.	2018	Unclear	Yes	Unclear	Unclear	No	No	No	Yes	Yes	Unclear	3/10
Gamal et al.	2019	No	No	No	No	No	No	No	Unclear	Yes	Unclear	1/10
Guner and Buyukbebeci	2013	Unclear	No	Unclear	Unclear	No	No	No	Yes	Yes	Unclear	2/10
Hermeto et al.	2016	Unclear	No	Unclear	Unclear	No	No	Yes	Unclear	Yes	Unclear	2/10
Jayaram et al.	2020	Unclear	No	Unclear	Unclear	No	No	Yes	Unclear	Yes	Unclear	2/10
Ji et al.	2015	Unclear	No	Unclear	Unclear	No	No	No	Yes	Yes	Unclear	2/10
Kanwat et al.	2017	No	Yes	No	No	No	No	Yes	Unclear	Yes	Unclear	3/10
Kutuk et al.	2014	No	No	No	Unclear	No	No	Yes	Yes	Yes	Unclear	3/10
Lu et al.	2020	Unclear	Yes	Unclear	Unclear	No	No	No	Yes	Yes	Unclear	3/10
Parlak and Arican	2020	Unclear	No	Unclear	No	No	No	No	Unclear	Yes	Unclear	1/10
Ragab et al.	2021	Unclear	Yes	Unclear	Unclear	No	No	Yes	Unclear	Yes	Unclear	3/10
Wang et al.	2018	Unclear	Unclear	Unclear	No	No	No	Yes	Yes	Yes	Unclear	3/10
Wu et al.	2016	Unclear	No	Unclear	Unclear	No	No	No	Yes	Yes	Unclear	2/10
Xin et al.	2020	Unclear	No	Unclear	No	No	No	No	Unclear	Yes	Unclear	1/10
Yin et al.	2016	Unclear	No	Unclear	Unclear	No	No	No	Unclear	Yes	Unclear	1/10
Yun et al.	2016	No	No	No	No	No	No	Yes	Unclear	Yes	Unclear	2/10

Note YES answers indicated low risk of bias, NO indicated high risk of bias, and UNCLEAR indicated it was not possible to assign bias. Criteria used for publication risk of bias analysis: (1) Was the allocation sequence adequately generated and applied? (2) Were the groups similar at baseline or were they adjusted for confounders in the analysis? (3) Was the allocation adequately concealed? (4) Were the animals randomly housed during the experiment? (5) Were the caregivers and/or investigators blinded from knowledge which intervention each animal received during the experiment? (6) Were animals selected at random for outcome assessment? (7) Was the outcome assessor blinded? (8) Were incomplete outcome data adequately addressed? (9) Are reports of the study free of selective outcome reporting? (10) Was the study apparently free of other problems that could result in high risk of bias?

ISSN: 2523-3106