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Fig. 5 | Advances in Rheumatology

Fig. 5

From: Tetramethylpyrazine alleviates hypoxia-induced proliferation, migration, and inflammatory response of fibroblast-like synoviocytes via inhibiting the HIF-1α- circCDC42BPB pathway

Fig. 5

Hypoxia-induced RA-FLS migration and inflammatory response were regulated by TMP/circCDC42BPB. RA-FLSs were treated with vector, hypoxia + vector, hypoxia + TMP + vector, or hypoxia + TMP + OE-circCDC42BPB. (A and B) RA-FLS migration was monitored by wound healing and transwell assays (one-way ANOVA). (C) MMP2 and MMP9 protein levels were tested using western blot in treated RA-FLSs (one-way ANOVA). (D) ELISA kits were applied to measure IL-6 and IL-8 secretions in RA-FLSs (one-way ANOVA). **P < 0.01, ***P < 0.001, n = 3

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Advances in Rheumatology

ISSN: 2523-3106