Skip to main content
Fig. 2 | Advances in Rheumatology

Fig. 2

From: Tetramethylpyrazine alleviates hypoxia-induced proliferation, migration, and inflammatory response of fibroblast-like synoviocytes via inhibiting the HIF-1α- circCDC42BPB pathway

Fig. 2

Effects of TMP on RA-FLS migration and inflammatory response under hypoxic conditions. RA-FLSs were treated with hypoxic conditions for 24 h in the presence or absence of TMP. (A and B) Wound healing and transwell assays were used to detect RA-FLS migration (one-way ANOVA). (C) Western blot assay was performed to determine the protein levels of MMP2 and MMP9 (one-way ANOVA). (D) Concentration of cytokines (IL-6 and IL-8) in RA-FLS cells culture medium of different groups was measured by ELISA Kits (one-way ANOVA). *P < 0.05, **P < 0.01, ***P < 0.001, n = 3

Back to article page

Advances in Rheumatology

ISSN: 2523-3106