Variable | Baricitinib (n = 74) | Tofacitinib (n = 105) | P-value | |
---|---|---|---|---|
Age (years) | 50.0 (33.0–58.8) | 50.0 (42.5–56.5) | 0.48 | |
Sex, n (% female) | 63 (85.1%) | 86 (81.9%) | 0.57 | |
RA duration (months) | 12.0 (7.0–36.0) | 12.0 (6.0–60.0) | 0.82 | |
glucocorticoid dosage at baseline(mg) | 2.0(0–4.0) | 0(0–4.0) | 0.14 | |
Number of patients with previous use of DMARDs | Â | Â | Â | |
1 class | 31(41.9%) | 50(47.6%) | 0.49 | |
2 classes | 38(51.4%) | 51(48.6%) | 0.71 | |
3 classes | 5(6.8%) | 4(3.8%) | 0.37 | |
Hyperuricemia (n) | 2(2.7%) | 0 | 0.09 | |
Type II diabetes(n) | 1(1.4%) | 2(1.9%) | 0.78 | |
Hyperlipemia(n) | 0 | 2(1.9%) | 0.23 | |
Latent tuberculosis infection(n) | 2(2.7%) | 3(2.9%) | 0.95 | |
Hypertension(n) | 0 | 2(1.9%) | 0.64 | |
Hepatitis B indicates antigen carriage(n) | 4(5.4%) | 4(3.8%) | 0.61 | |
TJC | 6.0 (2.0–11.8) | 6.0 (2.0–12.0) | 0.36 | |
SJC | 5.5 (2.0–12.0) | 6.0 (2.0–12.0) | 0.57 | |
VAS | 5.5 (4.0–8.0) | 5.5 (3.0–8.0) | 0.28 | |
DAS28-CRP | 4.6 (3.7–6.2) | 4.9 (3.7–6.0) | 0.72 | |
WBC (×109/L) | 7.5 (6.7–9.8) | 7.3 (6.1–9.4) | 0.36 | |
HGB (g/L) | 113.7 ± 15.2 | 116.8 ± 11.5 | 0.11 | |
PLT (×109/L) | 331.7 (271.0–434.7) | 334.7 (274.0–423.8) | 0.91 | |
NEU (×109/L) | 5.3 (4.2–6.9) | 5.0 (3.8–6.7) | 0.54 | |
LYM (×109/L) | 1.8 (1.3–2.2) | 1.7 (1.3–2.0) | 0.33 | |
AST (U/L) | 24.5 (19.0–30.0) | 25.0 (21.0–29.5) | 0.50 | |
ALT (U/L) | 12.0 (10.0–20.0) | 14.0 (9.0–22.0) | 0.78 | |
CREA (µmol/L) | 53.0 (46.0–65.8) | 54.0 (46.5–65.0) | 0.64 | |
CRP (mg/L) | 16.9 (4.9–53.9) | 22.7 (8.3–61.4) | 0.46 | |
RF positive | 67(90.5%) | 94(91.3%) | 0.90 | |
ESR (mm/h) | 57.5 (35.0–82.8) | 62.0 (40.0–91.0) | 0.23 |