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Fig. 8 | Advances in Rheumatology

Fig. 8

From: Baricitinib improves pulmonary fibrosis in mice with rheumatoid arthritis-associated interstitial lung disease by inhibiting the Jak2/Stat3 signaling pathway

Fig. 8

Mechanism of action of baricitinib in the Jak2/Stat3 signaling pathway Baricitinib inhibits the Jak2/Stat3 pathway and interferes with p-Smad3 via p-Stat3, ultimately attenuating ECM deposition. One pathway is that TGFβR1 affects downstream Smad3/pSMAD3. The other pathway is that cytokine stimulation of downstream Jak2/p-Jak2 affects Stat3/p-Stat3. Baricitinib affects p-Smad3 via p-Jak2/p-Stat3. Inhibition of p-Smad3 and p-Stat3 promotes the transformation of fibroblasts to myofibroblasts, thereby further reducing the deposition of FN, SMA and ECM. Inhibition of p-Smad3 and p-Stat3 promotes the transformation of fibroblasts to myofibroblasts, which further attenuates the deposition of FN, SMA, and ECM, and ultimately reduces pulmonary fibrosis

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Advances in Rheumatology

ISSN: 2523-3106