Table 3 Gene polymorphism from SRs

Risk

Chang [33]

BLK, rs4840568

A versus G: OR = 1.32, 95% CI = 1.22–1.43, P = 0.010

Song [34]

BLK, rs13277113

A allele: OR = 1.36, 95% CI = 1.29–1.43, P < 0.001

Xiong [31]

VDR BsmI, rs1544410

BB + Bb versus bb: OR = 2.14, 95% CI = 1.20–3.82, P = 0.010

Lee [39]

TNF-α promoter-308 A/G

A/A: OR = 3.2, 95% CI = 2.0–5.3, P < 0.001

Zou [40]

TNF-α promoter-308 A/G

A allele: OR = 1.44, 95% CI = 1.04–2.01, P = 0.030

Pan [41]

TNF-α promoter-308 A/G

A/A versus G/G: OR = 3.69, 95% CI = 2.63–5.17, P < 0.001

Yang [42]

TNF-α promoter-308 A/G

A allele: OR = 2.18, 95% CI = 1.72–2.78, P < 0.001

Chen [43]

TNF-α promoter-308 A/G

A versus G: OR = 1.78, 95% CI = 1.45–2.19, P < 0.001

Fan [44]

TNFAIP3, rs2230926

OR = 1.83, 95% CI = 1.55–2.16, P < 0.001

Lee [45]

TNFAIP3, rs2230926

OR = 1.85, 95% CI = 1.55–2.21, P < 0.001

Liu [47]

TNFAIP3, rs2230926

G allele: OR = 1.64, 95% CI = 1.46–1.85, P < 0.010

Lu [48]

TNFSF4, rs2205960

OR = 1.33, 95% CI = 1.23–1.44, P < 0.001

Wang [49]

TNFSF4, rs2205960

OR = 1.93, 95% CI = 1.50–2.49, P < 0.001

Moreno-Eutimio [51]

TNFSF4, rs2205960

G vs T: OR = 1.32, P = 0.004

Fu [50]

TNFSF4, rs2205960

OR = 1.42, 95% CI = 1.36–1.49, P < 0.001

Xu [52]

TRAF1/C5, rs10818488

OR = 1.25, 95% CI = 1.06–1.47, P = 0.008

Zhu [53]

IL-1B -31 T/C

OR = 1.64, 95% CI = 1.03–2.62, P = 0.040

Wang [58]

IL-10-1082A/G, rs1800896

OR = 1.20, 95% CI = 1.03–1.41

Yin [28]

IL-10-1082A/G, rs1800896

GG versus AA: OR = 1.54, 95% CI = 1.14–2.07, P = 0.005

Niu [62]

HLA-DR3, DR9, DR15

HLA-DR3: OR = 1.88, 95% CI = 1.58–2.23, P < 0.001

Xue [63]

HLA-DR3, DR15

HLA-DR15: OR = 1.68, 95% CI = 1.33–2.11, P = 0.001

Hu [65]

IRF5, rs2004640

OR = 1.41, 95% CI = 1.34–1.49, P < 0.001

Wang [66]

IRF5, rs2004640

OR = 1.39, 95% CI = 1.28–1.52, P < 0.001

Li [67]

IRF5, rs2070197

OR = 2.13, 95% CI = 1.86–2.44, P < 0.001

Ji [68]

STAT4, rs7574865

OR = 1.57, 95% CI = 1.44–1.71

Yuan [69]

STAT4, rs7574865

OR = 1.65, 95% CI = 1.56–1.75, P < 0.001

Wang [70]

STAT4, rs7574865

OR = 1.56, 95% CI = 1.51–1.61, P < 0.001

Ji [73]

MiR-146a, rs2431697

OR = 1.24, 95% CI = 1.13–1.37

Liu [75]

MiR-146a, rs2431697

OR = 1.56, 95% CI = 1.20–1.92, P = 0.001

Fan [77]

ITGAM, rs1143679

AA versus GG: OR = 3.54, 95% CI = 2.77–4.52

Ebrahimiyan [76]

ITGAM, rs1143679

OR = 1.97, 95% CI = 1.76–2.20, P < 0.001

Protective

Niu [62]

HLA-DR4, DR11, DR14

HLA-DR14: OR = 0.47, 95% CI = 0.59–0.95, P < 0.050

Hu [65]

IRF5, rs729302, rs2280714

rs729302: OR = 0.78, 95% CI = 0.74–0.83, P < 0.001

Ebrahimiyan [76]

MBL, rs1800451

OR = 0.64, 95% CI = 0.42–0.99, P = 0.044

Contradictory

Yu [38]

CTLA-4, rs231775

No association

Chang [36]

CTLA-4, rs231775

GG versus AA: OR = 1.53, 95% CI = 1.12–2.10

Zhai [37]

CTLA-4, rs231775

GG + GA versus AA: OR = 0.85, 95% CI = 0.73–0.99, P = 0.040

Lee [35]

CTLA-4, rs231775

GG genotype: OR = 1.29, 95% CI = 1.03–1.56, P = 0.011

Lee [54]

IL-6–174 G/C, rs1800795

OR = 1.34, 95% CI = 1.05–1.72, P = 0.018

Yang [55]

IL-6–174 G/C, rs1800795

OR = 1.64, 95% CI = 1.10–2.45, P = 0.016

Cui [56]

IL-6–174 G/C, rs1800795

OR = 1.61, 95% CI = 1.16–2.24

Liu [57]

IL-6–174 G/C, rs1800795

OR = 0.71, 95% CI = 0.56–0.88, P = 0.020

Yang [55]

IL-6–572 G/C, rs1800796

OR = 1.49,95% CI = 1.10–2.01, P = 0.009

Liu [57]

IL-6–572 G/C, rs1800796

No association

Lee [54]

IL-6–572 G/C, rs1800796

No association

Wen [61]

IL-18-137G/C, rs187238

OR = 1.21, 95% CI = 0.91–1.60

Chen [60]

IL-18-137G/C, rs187238

OR = 1.17, 95% CI = 0.95–1.44, P = 0.150

Ji [73]

MiR-146a, rs57095329

OR = 1.25, 95% CI = 1.17–1.35

Fu [74]

MiR-146a, rs57095329

OR = 1.26, 95% CI = 1.14–1.41

Liu [75]

MiR-146a, rs57095329

OR = 1.17, 95% CI = 0.84–1.65, P = 0.360

Unrelated

Yin [28]

IL-10, rs1800871, rs1800872

NA

Yuan [59]

IL-10, rs1800871, rs1800872

NA

Niu [62]

HLA-DR8

NA