Table 4 Haplotype frequency estimation and haplotype association analysis, with respect to the TP53 polymorphisms, rs1042522 (G > C) and rs17878362 (16 bp Del/Ins), and the SNPs in the p21 (CDKN1A) gene, rs1801270 (C > A) and rs1059234 (C > T), in the entire study sample and in the groups stratified according skin color/ethnicity
From: TP53 and p21 (CDKN1A) polymorphisms and the risk of systemic lupus erythematosus
Haplotype | Total group | Whites | Non-whites | ||||||
|---|---|---|---|---|---|---|---|---|---|
Controls (f) | Cases (f) | OR (95% CI) | Controls (f) | Cases (f) | OR (95% CI) | Controls (f) | Cases (f) | OR (95% CI) | |
TP53 rs17878362-rs1042522 | |||||||||
A1–G | 0.565 | 0.572 | 1.00 | 0.766 | 0.583 | 1.00 | 0.520 | 0.565 | 1.00 |
A1–C | 0.255 | 0.223 | 0.85 (0.56–1.30) | 0.203 | 0.167 | 1.40 (0.52–3.75) | 0.268 | 0.255 | 0.88 (0.54–1.43) |
A2–C | 0.170 | 0.200 | 1.14 (0.75–1.71) | 0.031 | 0.250 | 9.67 (2.02–46.28)a | 0.200 | 0.172 | 0.81 (0.49–1.35) |
A2–G | 0.010 | 0.005 | 0.62 (0.09–4.22) | 0 | 0 | NA | 0.013 | 0.008 | 0.69 (0.10–4.64) |
Global haplotype association p value | 0.69 | < 0.001 | 0.83 | ||||||
p21 rs1801270-rs1059234 | |||||||||
C–C | 0.743 | 0.766 | 1.00 | 0.759 | 0.787 | 1.00 | 0.744 | 0.755 | 1.00 |
A–T | 0.202 | 0.167 | 0.80 (0.51–1.24) | 0.167 | 0.162 | 0.98 (0.39–2.49) | 0.206 | 0.170 | 0.80 (0.47–1.35) |
A–C | 0.035 | 0.036 | 0.97 (0.37–2.52) | 0 | 0.026 | NA | 0.042 | 0.041 | 0.94 (0.33–2.69) |
C–T | 0.019 | 0.031 | 1.49 (0.52–4.27) | 0.074 | 0.026 | 0.42 (0.09–2.09) | 0.008 | 0.034 | 4.46 (0.84–23.74) |
Global haplotype association p value | 0.65 | 0.34 | 0.23 | ||||||