Table 3 Genotype interactions of the TP53 rs1042522 (G > C), TP53 rs17878362 (16 bp Del/Ins), p21 rs1801270 (C > A) and p21 rs1059234 (C > T) polymorphisms between the group and subgroups of cases and controls stratified by skin color/ethnicity
From: TP53 and p21 (CDKN1A) polymorphisms and the risk of systemic lupus erythematosus
Genotype combinationa | Total group | Whites | Non-whites | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
TP53 rs104252253 G > C | TP53 rs17878362 16 bp Del/Ins | p21 rs1801270 C > A | p21 rs1059234 C > T | Controls n | Cases n | OR (95% CI) | Controls n | Cases n | OR (95% CI) | Controls n | Cases n | OR (95% CI) |
GG | A1A1 | 63 | 36 | 1.00 | 18 | 12 | 1.00 | 44 | 24 | 1.00 | ||
GC | A1A1 | 55 | 39 | 1.24 (0.70–2.22) | 11 | 13 | 1.77 (0.60–5.25) | 44 | 26 | 1.08 (0.54–2.17) | ||
GC | A1A2 | 30 | 22 | 1.28 (0.65–2.55) | 2 | 12 | 9.00 (1.70–47.62)b | 28 | 10 | 0.65 (0.27–1.57) | ||
GG | CC | 36 | 22 | 1.00 | 9 | 10 | 1.00 | 27 | 12 | 1.00 | ||
GC | CC | 44 | 38 | 1.41 (0.71–2.80) | 9 | 15 | 1.50 (0.44–5.10) | 35 | 23 | 1.37 (0.57–3.26) | ||
GC | CA | 30 | 16 | 0.87 (0.39–1.95) | 3 | 7 | 2.10 (0.41–10.67) | 27 | 9 | 0.75 (0.27–2.07) | ||
CC | CA | 15 | 11 | 1.20 (0.47–3.07) | 1 | 3 | 2.70 (0.24–30.86) | 14 | 8 | 1.29 (0.43–3.88) | ||
GG | CC | 32 | 21 | 1.00 | 7 | 9 | 1.00 | 25 | 12 | 1.00 | ||
GG | CT | 17 | 8 | 0.72 (0.26–1.96) | 6 | 1 | 0.13 (0.01–1.34) | 10 | 7 | 1.46 (0.44–4.78) | ||
GC | CC | 45 | 38 | 1.29 (0.64–2.59) | 9 | 15 | 1.30 (0.36–4.70) | 36 | 23 | 1.33 (0.56–3.16) | ||
GC | CT | 25 | 17 | 1.04 (0.45–2.37) | 2 | 7 | 2.72 (0.42–17.43) | 23 | 10 | 0.91 (0.33–2.49) | ||
CC | CT | 5 | 10 | 3.05 (0.91–10.19) | 1 | 1 | 0.78 (0.04–14.76) | 9 | 4 | 0.93 (0.24–3.62) | ||
A1A1 | CC | 66 | 52 | 1.00 | 16 | 19 | 1.00 | 50 | 33 | 1.00 | ||
A1A1 | CA | 48 | 17 | 0.45 (0.23–0.87)c | 10 | 3 | 0.25 (0.06–1.08) | 36 | 14 | 0.59 (0.28–1.26) | ||
A1A2 | CC | 30 | 11 | 0.46 (0.21–1.02) | 3 | 6 | 1.68 (0.36–7.84) | 27 | 5 | 0.28 (0.10–0.80)d | ||
A1A1 | CC | 62 | 46 | 1.00 | 14 | 17 | 1.00 | 48 | 29 | 1.00 | ||
A1A1 | CT | 40 | 19 | 0.64 (0.33–1.25) | 9 | 5 | 0.46 (0.12–1.68) | 29 | 14 | 0.80 (0.36–1.76) | ||
A1A1 | TT | 6 | 5 | 1.12 (0.32–3.91) | 2 | 2 | 0.82 (0.10–6.62) | 4 | 3 | 1.24 (0.26–5.95) | ||
A1A2 | CC | 30 | 19 | 0.85 (0.43–1.70) | 3 | 7 | 1.92 (0.42–8.84) | 27 | 12 | 0.74 (0.32–1.67) | ||
CC | CC | 89 | 68 | 1.00 | 16 | 25 | 1.00 | 73 | 43 | 1.00 | ||
CC | CT | 3 | 5 | 2.18 (0.50–9.45) | 1 | 2 | 1.28 (0.11–15.31) | 2 | 3 | 2.55 (0.41–15.86) | ||
CA | CT | 49 | 29 | 0.77 (0.44–1.35) | 8 | 9 | 0.72 (0.23–2.25) | 39 | 20 | 0.87 (0.45–1.68) | ||