Table 2 Analysis of interaction between the TP53 rs1042522 (G > C) and TP53 rs17878362 (16 bp Del/Ins) polymorphisms, skin color/ethnicity and development of SLE
From: TP53 and p21 (CDKN1A) polymorphisms and the risk of systemic lupus erythematosus
Polymorphism | Skin color/ethnicity | Genetic model | Controls n | Cases n | Adjusted OR (95% CI)c |
|---|---|---|---|---|---|
TP53 rs1042522 (G > C)a | White | GG | 18 | 12 | 1.00 |
GC | 14 | 25 | 2.73 (1.02–7.34)d | ||
CC | 1 | 5 | 7.88 (0.80–77.25) | ||
GG | 18 | 12 | 1.00 | ||
GC + CC | 15 | 30 | 3.06 (1.17–8.04)e | ||
GG + GC | 32 | 37 | 1.00 | ||
CC | 1 | 5 | 4.43 (0.49–40.17) | ||
GG + CC | 19 | 17 | 1.00 | ||
GC | 14 | 25 | 2.01 (0.80–5.080) | ||
Non-white | GG | 45 | 25 | 1.00 | |
GC | 74 | 36 | 0.85 (0.56–1.60) | ||
CC | 35 | 14 | 0.72 (0.32–1.59) | ||
GG | 45 | 25 | 1.00 | ||
GC + CC | 109 | 50 | 0.81 (0.45–1.47) | ||
GG + GC | 119 | 61 | 1.00 | ||
CC | 35 | 14 | 0.79 (0.39–1.59) | ||
GG + CC | 80 | 39 | 1.00 | ||
GC | 74 | 36 | 0.97 (0.55–69) | ||
TP53 rs17878362 (16 bp Del/Ins)b | White | A1A1 | 30 | 25 | 1.00 |
A1A2 | 3 | 13 | 5.22 (1.33–20.47)f | ||
A2A2 | 0 | 4 | NA | ||
A1A1 | 30 | 25 | 1.00 | ||
A1A2 + A2A2 | 3 | 17 | 6.93 (1.81–26.51)g | ||
A1A1 + A1A2 | 33 | 38 | 1.00 | ||
A2A2 | 0 | 4 | NA | ||
A1A1 + A2A2 | 30 | 29 | 1.00 | ||
A1A2 | 3 | 13 | 4.47 (1.15–17.33)h | ||
Non-white | A1A1 | 104 | 52 | 1.00 | |
A1A2 | 47 | 19 | 0.81 (0.43–1.52) | ||
A2A2 | 10 | 4 | 0.79 (0.24–2.64) | ||
A1A1 | 104 | 52 | 1.00 | ||
A1A2 + A2A2 | 57 | 23 | 0.80 (0.45–1.45) | ||
A1A1 + A1A2 | 151 | 71 | 1.00 | ||
A2A2 | 10 | 4 | 0.84 (0.25–2.77) | ||
A1A1 + A2A2 | 114 | 56 | 1.00 | ||
A1A2 | 47 | 19 | 0.82 (0.44–1.54) |