Table 1 Comparative analysis of genotype and allele distributions of the four polymorphisms, TP53 rs1042522 (G > C), TP53 rs17878362 (16 bp Del/Ins), p21 rs1801270 (C > A) and p21 rs1059234 (C > T), between the groups of cases and controls using different genetic models
From: TP53 and p21 (CDKN1A) polymorphisms and the risk of systemic lupus erythematosus
Polymorphism | Genotype/Allele | Controlsa n (%) or n (ƒ) | Casesb n (%) or n (ƒ) | p value c | Genetic model | Adjusted ORd (95% CI) | |
|---|---|---|---|---|---|---|---|
TP53 rs1042522 G > C | GG | 64 (34.0) | 37 (31.6) | 0.6424 | Codominant | GC vs. GG | 1.21 (0.71–2.08) |
GC | 88 (46.8) | 61 (52.1) | CC vs. GG | 1.09 (0.53–2.22) | |||
CC | 36 (19.1) | 19 (16.2) | Dominant | GC + CC vs. GG | 1.18 (0.71–1.97) | ||
G | 216 (0.57) | 135 (0.58) | 1.0000 | Recessive | CC vs. GG + GC | 0.97 (0.51–1.81) | |
C | 160 (0.43) | 99 (0.42) | Overdominant | GC vs. GG + CC | 1.18 (0.73–1.90) | ||
TP53 rs17878362 16 bp Del/Ins | A1A1 | 136 (69.4) | 77 (65.8) | 0.7349 | Codominant | A1A2 vs. A1A1 | 1.21 (0.70–2.07) |
A1A2 | 50 (25.5) | 32 (27.4) | A2A2 vs. A1A1 | 1.44 (0.53–3.92) | |||
A2A2 | 10 (5.1) | 8 (6.8) | Dominant | A1A2 + A2A2 vs. A1A1 | 1.25 (0.75–2.06) | ||
A1 | 322 (0.82) | 186 (0.79) | 0.4598 | Recessive | A2A2 vs. A1A1 + A1A2 | 1.37 (0.51–3.67) | |
A2 | 70 (0.18) | 48 (0.21) | Overdominant | A1A2 vs. A1A1 + A2A2 | 1.17 (0.69–1.99) | ||
p21 rs1801270 C > A | CC | 103 (57.5) | 83 (64.3) | 0.3696 | Codominant | CA vs. AA | 0.86 (0.52–1.41) |
CA | 66 (36.9) | 42 (32.6) | AA vs. AA | 0.54 (0.16–1.83) | |||
A/A | 10 (5.6) | 4 (3.1) | Dominant | CA + AA vs. CC | 0.81 (0.50–1.32) | ||
C | 272 (0.76) | 208 (0.81) | 0.2005 | Recessive | AA vs. CC + CA | 0.58 (0.17–1.91) | |
A | 86 (0.24) | 50 (0.19) | Overdominant | CA vs. CC + AA | 0.89 (0.55–1.46) | ||
p21 rs1059234 C > T | CC | 104 (61.5) | 84 (65.6) | 0.7948 | Codominant | CT vs. CC | 0.88 (0.52–1.47) |
CT | 55 (32.5) | 37 (28.9) | TT vs. CC | 0.89 (0.32–2.46) | |||
TT | 10 (5.9) | 7 (5.5) | Dominant | CT + TT vs. CC | 0.88 (0.54–1.43) | ||
C | 263 (0.78) | 205 (0.80) | 0.5437 | Recessive | TT vs. CC + CT | 0.92 (0.34–2.54) | |
T | 75 (0.22) | 51 (0.20) | Overdominant | CT vs. CC + TT | 0.88 (0.53–1.48) | ||