Fig. 3

Representative FACS plots for the cytokine production of naive (A–D) and non-naive (E–H) CD4⁺ T-cells of Patient 1 with RA (Table 1) after Th17 stimulation. Data in the upper right area of each FACS plot indicate the percentage of IL-17⁺, IL-9⁺, IL-17⁺/IL-9⁺ and IL-17⁻/IL-9⁻ CD4⁺ T-cells in the naive and non-naive fraction. A and E IL-17 and IL-9 production of naive/non-naive CD4⁺ T-cells without MSCs (MSC−); B and F IL-17 and IFNγ production of naive/non-naive CD4⁺ T-cells without MSCs (MSC−); C and G IL-17 and IL-9 production of naive/non-naive CD4⁺ T-cells with MSCs (MSC+); D and H IL-17 and IFNγ production of naive/non-naive CD4⁺ T-cells with MSCs (MSC+)