Table 1 The general characteristics of the enrolled 79 IIM cases
From: Fever in the initial stage of IIM patients: an early clinical warning sign for AE-ILD
non-Fever n = 51 | Fever n = 28 | p-value | |
|---|---|---|---|
Patients’ characteristics | |||
Age at onset (years) | 49.71 ± 12.81 | 58.29 ± 11.27 | 0.004* |
Delay of diagnosis (months) | 3(0, 108) | 2(0, 180) | 0.075 |
Male (n, %) | 8(15.7) | 6(21.4) | 0.740 |
Complications (n, %) | 16(31.4) | 10(35.7) | 0.694 |
IIM type (n, %) | |||
DM | 15(29.4) | 8(28.6) | 0.937 |
PM | 15(29.4) | 5(17.9) | 0.259 |
CADM | 21(41.2) | 15(53.6) | 0.290 |
Clinical manifestations(n, %) | |||
Characteristics rashes | 34(66.7) | 22(78.6) | 0.265 |
Mechanic’s hands | 20(39.2) | 18(64.3) | 0.033* |
Raynaud’s phenomenon | 5(9.8) | 4(14.3) | 0.818 |
Muscle involvement | 28(54.9) | 11(39.3) | 0.184 |
Dysphagia | 9(17.7) | 2(7.1) | 0.342 |
Joint involvement | 14(27.5) | 6(21.4) | 0.556 |
ILD | 33(64.7) | 25(89.3) | 0.018* |
Laboratory tests | |||
NLR | 3.53(0.81, 20.64) | 4.27(1.93, 21.57) | 0.094 |
CRP (mg/ml) | 1.50(0.50, 28.90) | 6.85(0.5, 46.2) | 0.001* |
ESR (mm/H) | 18(3, 80)a | 50(5, 110) | 0.000* |
CK (U/L) | 330(26, 14,352) | 90(14, 7767) | 0.012* |
ALB (g/L) | 34.10(26.80, 44.60)a | 31.70(19.30, 38.70) | 0.003* |
PaO2/FiO2 | 453.71 ± 72.55b | 420.37 ± 123.47c | 0.168 |
Fer (ng/ml) | 197.25(4.60, 1485.90)d | 560.95(75.00, 1500.00)e | 0.121 |
Myositis-specific autoantibodies(n, %) | |||
ASS | 23(45.1) | 14(50.0) | 0.676 |
Anti-MDA5 | 13(25.5) | 12(42.9) | 0.112 |
RO-52(n, %) | 32(62.8) | 19(67.9) | 0.650 |
ANA (n, %) | 24(47.1) | 13(46.4) | 0.957 |
Treatments | |||
Glucocorticoid (mg/d) | 70(30, 300) | 100(50, 300) | 0.033* |
Immunosuppressants (n, %) | 0.044* | ||
MMF | 24(47.1) | 13(46.4) | |
CNIs | 19(37.3) | 15(53.6) | |
Others | 6(11.8) | 0(0.0) | |
None | 2(3.9) | 0(0.0) | |
IVIG (n, %) | 7(13.7) | 10(35.7) | 0.023* |