Fig. 3
From: Triptolide regulates the balance of Tfr/Tfh in lupus mice
Triptolide increased Foxp3+CXCR5+Tfr and Tfr/Tfh in MRL/lpr mice. A Representative staining of Tfr (CD4+Foxp3+CXCR5+) cells and Tfh (CD4+Foxp3−CXCR5+) among CD4+ T splenocytes in triptolide-treated MRL/lpr mice and vehicle-treated MRL/lpr mice. B The percentage of CD4+Foxp3+CXCR5+ Tfr cells in spleen of triptolide-treated MRL/lpr mice (n = 10) was significantly higher than that in vehicle-treated MRL/lpr mice (n = 8). C The percentage of CD4+Foxp3−CXCR5+ Tfh cells in spleen of two groups of mice showed no difference. D The ratio of Tfr and Tfh in spleen of triptolide-treated MRL/lpr mice was significantly higher than that in vehicle-treated MRL/lpr mice. *p < 0.05; ** p < 0.01