Fig. 1

Comparisons of frequencies of Tfr cells, Tfh cells and Tfr/Tfh ratio in MRL/lpr mice (n = 8) and controlled mice (C3H) (n = 6). A Representative staining of Tfr (CD4⁺Foxp3⁺CXCR5⁺) cells and Tfh (CD4⁺Foxp3⁻CXCR5⁺) among CD4⁺ T splenocytes in MRL/lpr lupus mice and controlled mice (C3H). B The percentage of CD4⁺Foxp3⁺CXCR5⁺ Tfr cells in spleen of MRL/lpr mice was significantly lower than that in controlled mice (C3H). C The percentage of CD4⁺Foxp3⁻CXCR5⁺Tfh cells in spleen of MRL/lpr mice was significantly higher than controlled mice (C3H). D The ratio of Tfr/Tfh in spleen of MRL/lpr mice was significantly lower than that in controlled mice (C3H) *p < 0.05, ** p < 0.01