Clinical manifestations, outcomes, and antibody profile of Brazilian adult patients with dermatomyositis: a single-center longitudinal study

Table 5 Autoantibodies and their association with specific sets of clinical, imaging, and laboratory features of dermatomyositis using a univariate binary logistic regression

Characteristics	ANA (n = 62)		Anti-ARS (n = 13)		Anti-MDA-5 (n = 10)		Anti-Ro-52 (n = 26)
Characteristics	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)
Male gender	NS	NS	NS	NS	0.025	4.90 (1.22–19.69)	NS	NS
Heliotrope rash	0.043	3.63 (1.04–12.64)	NS	NS	NS	NS	NS	NS
“V”-neck sign	NS	NS	< 0.001	0.07 (0.02–0.28)	NS	NS	NS	NS
“Shawl” sign	NS	NS	0.021	0.22 (0.06–0.79)	NS	NS	NS	NS
Raynaud’s phenomenon	0.040	2.58 (1.05–6.39)	NS	NS	NS	NS	NS	NS
“Mechanics’ hands”	NS	NS	0.010	5.30 (1.49–18.90)	NS	NS	0.011	4.30 (1.41–13.13)
Digital ulcers	NS	NS	NS	NS	0.003	9.67 (2.16–43.22)	NS	NS
Vasculitis	NS	NS	NS	NS	0.003	12.00 (2.31–62.46)	NS	NS
Arthritis	NS	NS	NS	NS	0.034	4.78 (1.12–20.36)	0.011	3.67 (1.34–10.03)
ILD	NS	NS	0.011	5.38 (1.47–19.72)	NS	NS	NS	NS
RP-ILD	NS	NS	NS	NS	NS	NS	0.035	3.82 (1.10–13.28)
Anti-ARS	NS	NS	–	–	NS	NS	0.035	3.82 (1.10–13.28)
Anti-MDA-5	NS	NS	NS	NS	–	–	0.021	5.53 (1.29–23.68)
Anti-Ro-52	NS	NS	0.035	3.82 (1.10–13.28)	0.021	5.53 (1.29–23.68)	NS	NS
Active disease	NS	NS	NS	NS	0.013	6.11 (1.47–25.43)	NS	NS

No association was found between anti-Mi-2 and the several clinical, imaging, and laboratory characteristics assessed
The following characteristics had no statistical association with specific autoantibodies and therefore were not included in the table: age at diagnosis (years), ethnicity, fever/weight loss, Gottron’s sign or papules, calcinosis, muscle weakness, dysphagia, maximum CPK, ANA, anti-Mi-2, severe infections, neoplasia, complete clinical response, disease remission, and death
ANA, antinuclear antibody; ARS, anti-tRNA synthetase; CPK, creatine phosphokinase; ILD, interstitial lung disease; NS, not significant; P, two-tailed P-value; RP, rapidly progressive

ISSN: 2523-3106