Serum MMP-9, SP-D, and VEGF levels reflect the severity of connective tissue disease-associated interstitial lung diseases

Table 3 Correlation analysis of serum marker level and traditional laboratory indicators in CTD-ILD

Indicators	MMP-9 (ng/ml)		SP-D (ng/ml)		VEGF (pg/ml)
Indicators	r	P	r	P	r	P
ESR	− 0.181	0.313	0.094	0.603	− 0.129	0.474
CRP	− 0.011	0.952	0.351	0.045^*	0.012	0.946
RF	0.039	0.758	0.177	0.325	0.081	0.653
IgG	0.093	0.608	0.180	0.317	0.195	0.276
IgA	− 0.074	0.684	− 0.032	0.859	− 0.268	0.132
IgM	0.007	0.968	0.080	0.659	0.038	0.833
C3	− 0.034	0.849	0.260	0.144	− 0.050	0.784
C4	− 0.122	0.498	− 0.179	0.318	− 0.036	0.840
WBC	0.040	0.824	0.057	0.752	0.305	0.084
NEU	0.237	0.185	0.023	0.899	0.064	0.723
Positive anti− CCP antibody	− 0.063	0.726	0.249	0.163	0.098	0.589
Positive ANA antibody	0.025	0.890	− 0.029	0.875	− 0.021	0.906
Positive SSA antibody	− 0.089	0.622	− 0.071	0.696	0.015	0.935
Positive SSB antibody	− 0.199	0.266	− 0.299	0.091	− 0.205	0.253
Positive p-ANAC antibody	0.275	0.122	0.134	0.458	0.193	0.282
Positive c-ANAC antibody	− 0.093	0.607	− 0.279	0.093	− 0.056	0.758

* mean P < 0.05 (correlation was considered significant)
ESR erythrocyte sedimentation rate, CRP c-reactive protein, RF rheumatoid factors, IgG immunoglobulin G, C3 complement C3, WBC whitebloodcell, NEU neutrophilic granulocyte, CCP cyclic cirullinated peptide, ANA antinuclear antibody, SSA anti-Sjogren syndrome A antibody, ANCA anti-neutrophil cytoplasmic antibody

ISSN: 2523-3106