High YKL-40 serum levels and its expression in the muscle tissues of patients with antisynthetase syndrome

Table 3 Correlation between YKL-40 serum levels and continuous variables (demographic, clinical, laboratory and lung parameters, and disease status) of the patients with antisynthetase syndrome

	*rho*	P
Demographic data
Age	0.294	0.040
Clinical parameters
Fever	0.070	0.631
Raynaud phenomenon	0.144	0.324
“Mechanic’s hands”	−0.045	0.757
Muscle involvement	−0.219	0.131
Joint involvement	−0.190	0.192
Laboratory parameters
TNF-α level	0.382	0.007
IFN-γ level	0.125	0.395
Lung involvement
FVC (% predict)	0.018	0.930
FEV1 (% predicted)	0.089	0.667
FEV1/FVC ratio	−0.066	0.758
DLCO₂ (% predicted)	0.533	0.091
Disease status
MMT-8	0.037	0.801
Patient’ VAS	−0.173	0.239
Physician’ VAS	−0.234	0.110
MYOACT	−0.077	0.614
HAQ	0.166	0.266
Creatine phosphokinase	0.131	0.371
Lactate dehydrogenase	0.138	0.460
Aspartate aminotransferase	0.033	0.854
Alanine aminotransferase	0.034	0.866
Treatment
Prednisone: dose (mg/day)	0.217	0.139

DLCO₂ diffusion of carbon dioxide; FEV1 forced expiratory volume in one second; FVC forced vital capacity; HAQ Health Assessment Questionnaire; IFN interferon; MMT-8 Manual Muscle Testing; MYOACT Myositis Disease Activity Assessment Visual Analogue Scales; TNF tumor necrosis factor; VAS Visual Analog Scale

ISSN: 2523-3106