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Fig. 5 | Advances in Rheumatology

Fig. 5

From: Long non-coding RNA KCNQ1OT1 promotes cell viability and migration as well as inhibiting degradation of CHON-001 cells by regulating miR-126-5p/TRPS1 axis

Fig. 5

LncRNA KCNQ1OT1 enhances the cell viability and migration but suppresses ECM degradation via sponging miR-126-5p to target TRPS1 in CHON-001 cells. a Relative expression of TRPS1 in CHON-001 cells was detected by qRT-PCR after transfection of sh-NC and sh-TRPS1. **P < 0.01, vs. sh-NC. b Relative expression of TRPS1 was determined by qRT-PCR in CHON-001 cells. ***P < 0.001, vs. pcDNA3.1-NC. ###P < 0.001, vs. pcDNA3.1-KCNQ1OT1. c The cell viability was determined by MTT assay in CHON-001 cells. ***P < 0.001, vs. pcDNA3.1-NC. ##P < 0.01, vs. pcDNA3.1-KCNQ1OT1. d Relative migration was assessed by transwell assay in CHON-001 cells. ***P < 0.001, vs. pcDNA3.1-NC. ##P < 0.01, vs. pcDNA3.1-KCNQ1OT1. e Relative protein expression of collagen II and MMP13 was determined by western blot in CHON-001 cells. ***P < 0.001, vs. pcDNA3.1-NC. ##P < 0.01, vs. pcDNA3.1-KCNQ1OT1

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Advances in Rheumatology

ISSN: 2523-3106