Table 5 Risk of ADRs in response to methotrexate (MTX) and glucocorticoids (GCs) based on logistic regression

Sex: male (ref-female)

1.01 (0.65–1.56)

0.978

1.04 (0.61–1.77)

0.882

Age (years)

0.84 (0.80–0.88)

< 0.001

–

–

Age ≤ 16 years (ref-more than 16 years)

9.45 (5.15–17.31)

< 0.001

9.68 (4.86–19.28)

< 0.001

 Subcutaneous

1.92 (1.07–3.44)

0.028

2.10 (1.05–4.20)

0.036

Dose

5.14 (2.14–12.36)

< 0.001

1.21 (0.4–3.68)

0.737

Dose of methotrexate ≥ 0.6 mg/kg/week (ref-more than 0,6)

2.09 (1.37–3.19)

0.001

–

–

 JSLE

0.62 (0.31–1.27)

0.195

2.4 (0.95–6.07)

0.064

 JDM

0.34 (0.19–0.61)

< 0.001

0.40 (0.2–0.79)

0.008

Variable

(IC95%)

p

(IC95%)

p

Sex: male (ref.- female)

0.55 (0.33–0.91)

0.02

1.10 (0.50–2.38)

0.816

Age (years)

0.86 (0.81–0.91)

< 0.001

–

–

Age ≤ 16 years

6.67 (3.69–12.07)

< 0.001

9.92 (4.36–22.54)

< 0.001

(ref.- more than 16 years)

Dose of glucocorticoid (oral)

5.63 (2,88-11,00)

< 0,001

–

–

Dose of glucocorticoid (oral) ≥ 0.5 mg/kg/day (ref.-less than 0.5)

2.51 (1.59–3.95)

< 0.001

1.88 (0.96–3.69)

0.067

30 mg/kg/dose (Pulse therapy)

0.26 (0.07–0.89)

0.033

0.54 (0.12–2.39)

0.42

 JIA

0.03 (0.02–0.06)

< 0.001

0.03 (0.01–0.06)

< 0.001

 JDM

0.07 (0.03–0.14)

< 0.001

0.05 (0.02–0.11)

< 0.001