|
Sex: male (ref-female)
|
1.01 (0.65–1.56)
|
0.978
|
1.04 (0.61–1.77)
|
0.882
|
|
Age (years)
|
0.84 (0.80–0.88)
|
< 0.001
|
–
|
–
|
|
Age ≤ 16 years (ref-more than 16 years)
|
9.45 (5.15–17.31)
|
< 0.001
|
9.68 (4.86–19.28)
|
< 0.001
|
|
Administration routes of methotrexate (ref-oral)
|
|
Subcutaneous
|
1.92 (1.07–3.44)
|
0.028
|
2.10 (1.05–4.20)
|
0.036
|
|
Dose
|
5.14 (2.14–12.36)
|
< 0.001
|
1.21 (0.4–3.68)
|
0.737
|
|
Dose of methotrexate ≥ 0.6 mg/kg/week (ref-more than 0,6)
|
2.09 (1.37–3.19)
|
0.001
|
–
|
–
|
|
Disease (ref.- JIA)
|
|
JSLE
|
0.62 (0.31–1.27)
|
0.195
|
2.4 (0.95–6.07)
|
0.064
|
|
JDM
|
0.34 (0.19–0.61)
|
< 0.001
|
0.40 (0.2–0.79)
|
0.008
|
| |
Logistic regression to glucocorticoid
|
|
Variable
|
OR
|
Adjusted OR
|
|
(IC95%)
|
p
|
(IC95%)
|
p
|
|
Sex: male (ref.- female)
|
0.55 (0.33–0.91)
|
0.02
|
1.10 (0.50–2.38)
|
0.816
|
|
Age (years)
|
0.86 (0.81–0.91)
|
< 0.001
|
–
|
–
|
|
Age ≤ 16 years
|
6.67 (3.69–12.07)
|
< 0.001
|
9.92 (4.36–22.54)
|
< 0.001
|
|
(ref.- more than 16 years)
|
|
Dose of glucocorticoid (oral)
|
5.63 (2,88-11,00)
|
< 0,001
|
–
|
–
|
|
Dose of glucocorticoid (oral) ≥ 0.5 mg/kg/day (ref.-less than 0.5)
|
2.51 (1.59–3.95)
|
< 0.001
|
1.88 (0.96–3.69)
|
0.067
|
|
30 mg/kg/dose (Pulse therapy)
|
0.26 (0.07–0.89)
|
0.033
|
0.54 (0.12–2.39)
|
0.42
|
|
Disease (ref.- JSLE)
|
|
JIA
|
0.03 (0.02–0.06)
|
< 0.001
|
0.03 (0.01–0.06)
|
< 0.001
|
|
JDM
|
0.07 (0.03–0.14)
|
< 0.001
|
0.05 (0.02–0.11)
|
< 0.001
|
