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Table 1 Baseline characteristics of the patients at the time of completing the MISS questionnaire

From: High frequency of methotrexate intolerance in longstanding rheumatoid arthritis: using the methotrexate intolerance severity score (MISS)

Characteristics

N = 120

Qualitative

 Female (%)

103 (85.8)

 MTX, subcutaneous (%)

66 (55)

 MTX dose (mg/week)

   < 10 (%)

1 (0.8)

  10.1–17.5 (%)

31 (25.8)

   > 17.5 (%)

88 (73.4)

 Leflunomide (%)

29 (24.2)

 Nonsteroidal anti-inflammatory drugs (%)

9 (7.5)

 Disease-modifying antirheumatic drugs – biological (%)

28 (23.3)

 Corticosteroids (%)

63 (52.5)

 Proton-pump inhibitors (%)

56 (46.7)

 Antiemetics (%)

1 (0.8)

 Folic acid

  No (%)

7 (5.8)

  5 mg/week (%)

92 (76.7)

  10 mg/week or more (%)

21 (17.5)

 DAS 28 moderate and high disease activity (%)

51 (45.5)

 Smoking

  No (%)

74 (62.2)

  Current smoker (%)

15 (12.6)

  Ex-smoker (%)

30 (25.2)

 Seropositive RA (%)

92 (76.7)

 Hypertension (%)

68 (56.7)

 Diabetes mellitus (%)

29 (24.2)

 Dyslipidemia (%)

36 (30.0)

 Hypothyroidism (%)

15 (12.5)

 Fibromyalgia (%)

10 (8.3)

 Gastroesophageal reflux disease (%)

12 (10.3)

 Antidepressant (%)

24 (20)

Quantitative

 Mean age, years (SD)

61 (12.5)

 Mean disease duration, years (SD)

16 (10.3)

 Mean MTX usage duration, years (SD)

7 (5.5)

 Mean dose of MTX, mg/week (SD)

20 (5.1)

 Mean DAS28 (SD)

3.25 (3.1)

  1. DAS 28 Disease activity score in 28 joints; MTX Methotrexate; SD Standard deviation