Table 3 Rheumatic manifestations in Fabry disease patients
From: Higher rate of rheumatic manifestations and delay in diagnosis in Brazilian Fabry disease patients
Signs/Symptoms/Diagnosis | Total N (%) | Males N (%) | Females N (%) | p-value |
|---|---|---|---|---|
Pain in the extremities (nociceptive and/or neuropathic) | 26 (70.3%) | 13 (81.3%) | 13 (61.9%) | 0.21 |
Fabry crises (past/present) | 15 (40.5%) | 10 (62.5%) | 5 (23.8%) | 0.02 |
Osteopenia/osteoporosis/ low bone mineral density for age | 24 (64.8%) | 13 (81.3%) | 11 (52.4%) | 0.07 |
Fibromyalgia | 16 (43.2%) | 6 (37.5%) | 10 (47.6%) | 0.55 |
Lymphedema | 8 (21.6%) | 7 (43.8%) | 1 (4.8%) | 0.003 |
Neuropathic osteoarthropathy (Charcot foot) (2 patients = toe amputation) | 4 (10.8%) | 3 (18.8%) | 1 (4.8%) | 0.18 |
Chronic low back pain | 5 (13.5%) | 1 (6.3%) | 4 (19%) | 0.27 |
Hip/knee osteoarthritis | 5 (13.5%) | 3 (18.8%) | 2 (9.5%) | 0.43 |
Gout | 1 (2.7%) | 0 | 1 (4.8%) | – |
Clinodactyly | 1 (2.7%) | 1 (6.3%) | 0 | – |
HyperCKemia | 1 (2.7%) | 1 (6.3%) | 0 | – |
Carpal tunnel syndrome | 3 (8.1%) | 0 | 3 (14.3%) | 0.12 |