Table 2 Meta-Analysis of the pooled association between KIR polymorphisms and SSc
From: Evaluation of the association between KIR polymorphisms and systemic sclerosis: a meta-analysis
KIR gene | No. of studies | SSc Positive (%), Negative (%) / Total | Control Positive (%), Negative (%) / Total | P-value | Pooled OR (95% CI) | Heterogeneity Test Q, I2%; P-value | Publication Bias (Begg’s Test, P-value; Egger’s test, P-value) | Effect Model |
|---|---|---|---|---|---|---|---|---|
2DL1 | 5 | 550 (96.3%), 21 (3.7%) / 571 | 765 (96.1%), 31 (3.9%) / 796 | 0.660 | 1.14 (0.64–2.0) | (3.17, 0.0%; P = 0.52) | (Begg’s Test, 0.99; Egger’s test, 0.43) | Fixed |
2DL2 | 5 | 283 (49.5%), 288 (51.5%) / 571 | 444 (55.8%), 352 (44.2%) / 796 | 0.875 | 0.94 (0.42–2.07) | (39.87, 89.97%; P < 0.001) | (Begg’s Test, 0.99; Egger’s test, 0.86) | Random |
2DL3 | 5 | 498 (87.2%), 73 (12.8%) / 571 | 710 (89.2%), 86 (10.8%) / 796 | 0.306 | 0.84 (0.60–1.17) | (4.02, 53%; P = 0.40) | (Begg’s Test, 0.70; Egger’s test, 0.59) | Fixed |
2DL4 | 4 | 467 (99.6%), 2 (0.4%) / 469 | 696 (100%), 0 (0%) /696 | 0.335 | 0.42 (0.07–2.47) | (0.2, 0.0%; P = 0.97) | (Begg’s Test, 0.99; Egger’s test, 0.81) | Fixed |
2DL5 | 4 | 180 (38.4%), 289 (61.6%) / 469 | 273 (39%), 423 (61%) / 696 | 0.465 | 0.91 (0.71–1.17) | (2.19, 0.0%; P = 0.53) | (Begg’s Test, 0.39; Egger’s test, 0.09) | Fixed |
2DS1 | 5 | 285 (49.9%), 286 (50.1%) / 571 | 427 (53.6%), 369 (46.4%) / 796 | 0.92 | 0.98 (0.60–1.58) | (13.76, 70.9%; P = 0.008) | (Begg’s Test, 0.99; Egger’s test, 0.73) | Random |
2DS2 | 5 | 322 (56.4%), 249 (43.6%) /571 | 445 (55.9%), 351 (44.1%) / 796 | 0.923 | 1.01 (0.81–1.26) | (3.29, 0.0%; P = 0.51) | (Begg’s Test, 0.29; Egger’s test, 0.17) | Fixed |
2DS3 | 5 | 193 (24.3%), 378 (75.7%) / 571 | 260 (32.7%), 536 (67.3%) / 796 | 0.582 | 1.07 (0.85–1.34) | (7.25, 44.89%; P = 0.122) | (Begg’s Test, 0.12; Egger’s test, 0.16) | Fixed |
2DS4 | 5 | 321 (56.2%), 250 (43.8%) / 571 | 395 (49.6%), 401 (50.4%) / 796 | 0.838 | 1.03 (0.75–1.45) | (2.61, 0.0%; P = 0.62) | (Begg’s Test, 0.85; Egger’s test, 0.19) | Fixed |
2DS5 | 4 | 164 (35%), 305 (65%) /469 | 258 (37.1%), 438 (62.9%) / 696 | 0.444 | 0.81 (0.47–1.39) | (9.11, 67.10%; P = 0.02) | (Begg’s Test, 0.99; Egger’s test, 0.73) | Random |
3DL1 | 5 | 535 (93.7%), 38 (6.3%) / 571 | 739 (92.8%), 57 (7.2%) / 796 | 0.683 | 1.09 (0.71–1.70) | (3.78, 0.0%; P = 0.43) | (Begg’s Test, 0.99; Egger’s test, 0.28) | Fixed |
3DL2 | 4 | 467 (99.6%), 2 (0.4%) / 469 | 692 (99.4%), 4 (0.6%) / 696 | 0.902 | 1.09 (0.27–4.40) | (0.38, 0.0%; P = 0.94) | (Begg’s Test, 0.90; Egger’s test, 0.53) | Fixed |
3DL3 | 4 | 467 (98.9%), 5 (1.1%) / 472 | 696 (99.6%), 3 (0.4%) /699 | 0.534 | 0.64 (0.155–2.63) | (0.001, 0.0%; P = 0.99) | (Begg’s Test, 0.99; Egger’s test, 0.60) | Fixed |
3DS1 | 5 | 256 (44.8%), 315 (5.2%) / 571 | 342 (43%), 454 (57%) / 796 | 0.377 | 1.10 (0.88–1.37) | (2.68, 0.0%; P = 0.61) | (Begg’s Test, 0.19; Egger’s test, 0.11) | Fixed |
2DP1 | 4 | 460 (98.1%), 9 (1.9%) / 469 | 672 (96.5%), 24 (3.5%) / 696 | 0.182 | 1.672 (0.79–3.56) | (6.99, 57.13%; P = 0.07) | (Begg’s Test, 0.73; Egger’s test, 0.56) | Fixed |
3DP1 | 3 | 150 (42.4%), 204 (57.6%) / 354 | 230 (39.6%), 351 (60.4%) / 581 | 0.152 | 1.28 (0.91–1.81) | (0.94, 0.0%; P = 0.62) | (Begg’s Test, 0.90; Egger’s test, 0.47) | Fixed |