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Table 1 Etiologic factors in erythema nodosum

From: Panniculitides of particular interest to the rheumatologist

Infections Pancreatic carcinoma
Streptococcal infections Medications
Mycobacterium tuberculosis Estrogens/oral contraceptive pills
Gastroenteritis due to Yersinia, Salmonella, and Campylobacter Penicillin
Deep fungal infections: Blastomycosis, Histoplasmosis, Coccidioidomycosis, Sporotrichosis, Aspergillosis Minocycline
Chlamydia pneumoniae Sulfonamides
Chlamydia trachomatis Halogens (bromides, iodides)
Mycoplasma pneumoniae infections Salicylates
Cat-scratch disease Chlorothiazides
Syphilis Phenytoin
Infectious mononucleosis Thalidomide
Herpes simplex Underlying disease processes
Cytomegalovirus infections Sarcoidosis (Lofgren’s syndrome)
Hepatitis B (infection or vaccine) Crohn’s disease
Hepatitis C infection Ulcerative colitis
Epstein–Barr virus Behçet’s disease
Protozoal infections: Toxoplasmosis, Ancylostomiasis, Amebiasis, Giardiasis, Ascariasis Sweet’s syndrome
Malignancy Reiter’s syndrome
Hodgkin’s lymphoma Takayasu’s arteritis
Acute myelogenous leukemia Hormonal states
Carcinoid tumor Pregnancy
  1. Main categories of etiologic factors are in boldface