CD4+CD69+ T cells and CD4+CD25+FoxP3+ Treg cells imbalance in peripheral blood, spleen and peritoneal lavage from pristane-induced systemic lupus erythematosus (SLE) mice

Table 1 Data represent plasma and PL levels (mean ± standard deviation) of interleukins in SLE induced and control mice on both periods T90 and T120

Interleukins	Periods (days)	Blood			PL
Interleukins	Periods (days)	Control n = 8	SLE-induced n = 13	p	Control n = 8	SLE-induced n = 13	p
IL-1	T90	74.6 ± 136.6	45.4 ± 20.7	0.289	5.7 ± 9.9	71.9 ± 45.6	0.114
IL-1	T120	223.4 ± 154.0	236.1 ± 239.5	1.000	8.9 ± 8.8	2.3 ± 2.2	0.450
IL-2	T90	3.3 ± 1.2	2.9 ± 1.4	0.616	0.9 ± 0.4	2.5 ± 0.9	0.057
IL-2	T120	7.5 ± 9.2	3.2 ± 1.9	0.817	2.1 ± 1.8	0.4 ± 0.3	0.007
TNFa	T90	9.1 ± 1.4	12.3 ± 3.9	< 0.048	0.8 ± 1.2	18.4 ± 11.8	0.057
TNFa	T120	6.0 ± 2.2	10.2 ± 6.2	< 0.001	3.1 ± 6.2	2.4 ± 3.2	0.314
TGF_β1	T90	1255.0 ± 821.4	2780.0 ± 1050.0	< 0.010	759.3 ± 1186.0	516.3 ± 337.8	1.000
TGF_β1	T120	4514.0 ± 2653.0	5498.0 ± 2184.0	0.415	318.1 ± 223.6	525.0 ± 110.3	0.039
TGF_β2	T90	38.7 ± 31.9	79.3 ± 28.6	< 0.027	376.3 ± 205.4	204.3 ± 102.1	0.228
TGF_β2	T120	125.8 ± 64.9	169.6 ± 68.0	0.031	294.4 ± 171.1	258.2 ± 98.1	0.451
TGFβ3	T90	6.4 ± 2.0	7.1 ± 1.5	0.404	16.3 ± 3.8	13.0 ± 6.2	0.400
TGFβ3	T120	6.9 ± 0.7	8.0 ± 2.4	0.400	16.7 ± 5.2	13.7 ± 5.9	0.291
IL-10	T90	10.7 ± 5.3	17.6 ± 25.9	0.923	3.7 ± 5.7	17.3 ± 10.6	0.114
IL-10	T120	8.3 ± 4.1	11.2 ± 6.2	0.379	7.8 ± 10.0	0.9 ± 0.6	0.007
IFNg	T90	3.7 ± 1.0	3.0 ± 1.1	0.245	1.1 ± 1.1	3.4 ± 2.6	0.229
IFNg	T120	85.8 ± 163.5	3.3 ± 3.3	0.239	1.3 ± 1.1	0.3 ± 0.1	0.119

p < 0.05 are set in bold
IL = interleukin; IFN = interferon; TNF = tumor necrosis factor; TGF = transforming growth factor

ISSN: 2523-3106