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Table 3 Evaluation of joint pain and swelling and of the use of rescue therapy per visit in ITT population (N = 89)

From: Multicenter, randomized, double-blind clinical trial to evaluate efficacy and safety of combined glucosamine sulfate and chondroitin sulfate capsules for treating knee osteoarthritis

  Glucosamine sulfate and chondroitin sulfate (n = 45) Cosamin DS® (n = 44)
N % N % p-value
Absence of pain at joint pain evaluation V1 (Baseline) 1 2,2 3 6,8 0.361
V2 (Day 37) 6 13,3 8 18,2 0.573
V3 (Day 67) 10 22,2 8 18,2 0.793
V4 (Day 97) 17 37,8 17 38,6 > 0.999
V5 (Day 127) 30 66,7 23 52,3 0.198
Absence of joint swelling V1 (Baseline) 37 82,2 36 81,8 > 0.999
V2 (Day 37) 37 82,2 37 84,1 > 0.999
V3 (Day 67) 41 91,1 36 81,8 0.230
V4 (Day 97) 42 93,3 39 88,6 0.485
V5 (Day 127) 44 97,8 42 95,5 0.616
Joint pain evaluation
 No pain V1 (Baseline) 1 2,2 3 6,8 0.361
V2 (Day 37) 6 13,3 8 18,2 0.573
V3 (Day 67) 10 22,2 8 18,2 0.793
V4 (Day 97) 17 37,8 17 38,6 > 0.999
V5 (Day 127) 30 66,7 23 52,3 0.198
Subject reports pain V1 (Baseline) 22 48,9 19 43,2 0.672
V2 (Day 37) 28 62,3 25 56,8 0.669
V3 (Day 67) 22 48,9 27 61,4 0.289
V4 (Day 97) 20 44,4 20 45,5 > 0.999
V5 (Day 127) 9 20,0 25 34,1 < 0.001
 Subject reports pain and changes facial expression V1 (Baseline) 20 44,4 20 45,5 > 0.999
V2 (Day 37) 11 24,4 9 20,5 0.800
V3 (Day 67) 12 26,7 8 18,2 0.448
V4 (Day 97) 8 17,8 6 13,6 0.772
V5 (Day 127) 6 13,3 6 13,6 > 0.999
 Subject reports pain, changes facial expression and makes moves to cut limb V1 (Baseline) 2 4,4 2 4,5 > 0.999
V2 (Day 37) 0 0 2 4,5 0.242
V3 (Day 67) 1 2,2 1 2,3 > 0.999
V4 (Day 97) 0 0 1 2,3 0.494
V5 (Day 127) 0 0 0 0 > 0.999
 Subjects receiving rescue medication V2 (Day 37) 39 86,7 40 90,9 0.739
V3 (Day 67) 41 91,1 36 81,8 0.230
V4 (Day 97) 41 91,1 38 86,4 0.522
V5 (Day 127) 36 80,0 33 75,0 0.619
 Quantity of rescue medication tablets taken (average ± SD) V2 (Day 37) 19,21 ± 16,52   13,95 ± 13,73   0.109
V3 (Day 67) 17,24 ± 13,55   13,11 ± 14,79   0.148
V4 (Day 97) 15,37 ± 12,28   12,87 ± 14,57   0.351
V5 (Day 127) 14,81 ± 10,92   15,09 ± 12,57   0.920
  1. SD standard deviation, ITT intention to treat, V visit