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Table 2 Frequency of clinical manifestations in 25 patients from Northeastern Brazil diagnosed with granulomatosis with polyangiitis (GPA) between 2005 and 2016

From: Granulomatosis with polyangiitis in Northeastern Brazil: study of 25 cases and review of the literature

Organ/system (n = 25) n (%) Clinical manifestation n (%)
Kidney 16 (64) Nephritic syndrome 13/16 (81)
Creatinine clearance < 50 mL/min at diagnosis 12/16 (75)
Microscopic hematuria at presentation 12/16 (75)
Proteinuria > 1 g/day (mg/24 h) 8/16 (50)
Proteinuria > 1 g/day (mg/24 h) at presentation 6/16 (38)
Nephrotic-range proteinuria 5/16 (31)
Chronic kidney disease requiring dialysis 4/16 (25)
Nose, ear, throat 16 (64) Sinusitis 15/16 (93)
Sensorineural deafness 3/16 (18)
Mastoiditis 2/16 (13)
Lung 15 (60) Pulmonary nodule 7/15 (47)
Alveolar hemorrhage 4/15 (27)
Bronchial stenosis 2/15 (13)
Constitutional manifestations 12 (48) Fever 9/12 (75)
Asthenia 2/12 (17)
Joints 11 (44) Oligo/polyarthritis 11/11 (100)
Skin 8 (32) Purpura of lower limbs 8/8 (100)
Churg-Strauss nodule 1/8 (13)
Peripheral nervous system 7 (28) Axonal polyneuropathy 4/7 (57)
Multiple mononeuritis 2/7 (28)
Facial nerve paralysis 1/7 (14)
Eyes 7 (28) Orbital pseudotumor 3/7 (42)
Scleritis 3/7 (42)
Conjunctivitis 2/7 (28)
Uveitis 1/7 (14)
Heart 4 (16) Mitral insufficiency 2/4 (50)
Congestive heart failure 1/4 (25)
Third-degree atrioventricular block 1/4 (25)
Central nervous system 1 (4) Transverse myelitis 1/1 (100)
Gastrointestinal tract 1 (4) Bloody diarrhea 1/1 (100)