Table 2 Frequency of clinical manifestations in 25 patients from Northeastern Brazil diagnosed with granulomatosis with polyangiitis (GPA) between 2005 and 2016
Organ/system (n = 25) | n (%) | Clinical manifestation | n (%) |
|---|---|---|---|
Kidney | 16 (64) | Nephritic syndrome | 13/16 (81) |
Creatinine clearance < 50 mL/min at diagnosis | 12/16 (75) | ||
Microscopic hematuria at presentation | 12/16 (75) | ||
Proteinuria > 1 g/day (mg/24 h) | 8/16 (50) | ||
Proteinuria > 1 g/day (mg/24 h) at presentation | 6/16 (38) | ||
Nephrotic-range proteinuria | 5/16 (31) | ||
Chronic kidney disease requiring dialysis | 4/16 (25) | ||
Nose, ear, throat | 16 (64) | Sinusitis | 15/16 (93) |
Sensorineural deafness | 3/16 (18) | ||
Mastoiditis | 2/16 (13) | ||
Lung | 15 (60) | Pulmonary nodule | 7/15 (47) |
Alveolar hemorrhage | 4/15 (27) | ||
Bronchial stenosis | 2/15 (13) | ||
Constitutional manifestations | 12 (48) | Fever | 9/12 (75) |
Asthenia | 2/12 (17) | ||
Joints | 11 (44) | Oligo/polyarthritis | 11/11 (100) |
Skin | 8 (32) | Purpura of lower limbs | 8/8 (100) |
Churg-Strauss nodule | 1/8 (13) | ||
Peripheral nervous system | 7 (28) | Axonal polyneuropathy | 4/7 (57) |
Multiple mononeuritis | 2/7 (28) | ||
Facial nerve paralysis | 1/7 (14) | ||
Eyes | 7 (28) | Orbital pseudotumor | 3/7 (42) |
Scleritis | 3/7 (42) | ||
Conjunctivitis | 2/7 (28) | ||
Uveitis | 1/7 (14) | ||
Heart | 4 (16) | Mitral insufficiency | 2/4 (50) |
Congestive heart failure | 1/4 (25) | ||
Third-degree atrioventricular block | 1/4 (25) | ||
Central nervous system | 1 (4) | Transverse myelitis | 1/1 (100) |
Gastrointestinal tract | 1 (4) | Bloody diarrhea | 1/1 (100) |