Fig. 2

Baricitinib exerted anti-inflammatory and anti-fibrotic effects in SSc-ILD mice through inhibiting both JAK2 and TGF-β1 signalling pathways. A The effects of baricitinib on the concentration of inflammatory factors in mice plasma, including IL-1β, IL-6,IL-4 and IL-10 (n = 6). mRNA expression of collagen in lung (B) and skin (C) tissue among three groups (n = 6). Western blot analysis of the protein levels of collagen, JAK2, p-JAK2, TGF-β1 and TGF-β receptors in lung (D) and skin (E) tissue among control, bleomycin and baricitinib groups (n = 3). Data are presented as the means ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001