Variables | Total N = 934 | Patients with anti-SSA and anti-SSB negativity N = 299 | Patients with anti-SSA and/or anti-SSB positivity N = 635 | p-value* |
---|---|---|---|---|
Autoantibodies, n (%) | ||||
ANA titres ≥ 1:320 | 258(27.6) | 56 (18.7) | 202 (31.8) | < 0.001 |
Positive anti-Ro52 | 533 (57.1) | 71 (23.7) | 462 (72.8) | < 0.001 |
Positive anti-CENP-B | 69 (7.4) | 38 (12.7) | 31 (4.9) | < 0.001 |
Positive anti-RNP | 66 (7.1) | 20 (6.7) | 46 (7.2) | 0.757 |
Positive AMA-M2 | 81 (8.7) | 29 (9.7) | 52 (8.2) | 0.444 |
Positive RF (> 20 IU/mL) | 380/864(44.0) | 62 (22.2) | 318 (54.4) | < 0.001 |
Hematological characteristics, n (%) | ||||
Leucopenia (< 4 × 109/L) | 243/924 (26.3) | 40 (13.4) | 203 (32.4) | < 0.001 |
Neutropenia (< 1.5 × 109/L) | 75/924 (8.1) | 11 (3.7) | 64 (10.2) | 0.001 |
Lymphopenia (< 0.8 × 109/L) | 71/924 (7.7) | 17 (5.7) | 54 (8.6) | 0.119 |
Anemia (< 110 g/L) | 179/924 (19.4) | 32 (10.7) | 147 (23.5) | < 0.001 |
Thrombocytopenia (100 × 109/L) | 105/924 (11.4) | 20 (6.7) | 85 (13.6) | 0.002 |
Hyper-IgA (> 3.78 g/L) | 247/917 (26.9) | 62 (20.9) | 185 (29.8) | 0.004 |
Hyper-IgG (> 16.2 g/L) | 416/917 (45.4) | 84 (28.3) | 332 (53.5) | < 0.001 |
Hyper-IgM (> 2.63 g/L) | 72/917 (7.9) | 29 (9.8) | 43 (6.9) | 0.136 |
Low C3 (< 0.7 g/L) | 196/912 (21.5) | 47 (15.9) | 149 (24.1) | 0.005 |
Low C4 (< 0.16 g/L) | 311/912 (34.1) | 75 (25.4) | 236 (38.2) | < 0.001 |
Elevated ESR (> 20 mm/h) | 430/868 (49.5) | 113 (39.5) | 317 (54.4) | < 0.001 |