Table 1 Clinical characteristics of pSS patients with and without anti-SSA and anti-SSB antibody negativity
Variables | Total N = 934 | Patients with anti-SSA and anti-SSB negativity N = 299 | Patients with anti-SSA and/or anti-SSB positivity N = 635 | p-value* |
|---|---|---|---|---|
Age (years), Mean ± SD | 57.0 ± 12.6 | 61.7 ± 10.2 | 54.8 ± 13.1 | < 0.001 |
Sex (female), n (%) | 800 (85.7) | 225 (75.3) | 575 (90.6) | < 0.001 |
Disease duration (months), M (IQR) | 925/36 (10–96) | 24 (6–60) | 48 (12–108) | < 0.001 |
Nationality, Han Chinese, n (%) | 883 (94.5) | 283 (94.6) | 600 (94.5) | 0.920 |
Others Chinese, n (%) | 51 (5.5) | 16 (5.4) | 35 (5.5) | |
Dry mouth, n (%) | 799 (85.5) | 262 (87.6) | 537 (84.6) | 0.215 |
Dry eyes, n (%) | 739 (79.1) | 240 (80.3) | 499 (78.6) | 0.554 |
Fatigue, n (%) | 466 (49.9) | 148 (49.5) | 318 (50.1) | 0.869 |
Arthralgia, n (%) | 361/925 (39.0) | 102 (34.5) | 259 (41.2) | 0.051 |
Dental caries, n (%) | 339/879 (38.6) | 100 (36.1) | 239 (39.7) | 0.308 |
Palpable purpura, n (%) | 60/926 (6.5) | 14.12 (4.1) | 48 (7.6) | 0.045 |
Parotid enlargement, n (%) | 131/932 (14.1) | 35 (11.7) | 96 (15.2) | 0.156 |
Lymphadenopathy, n (%) | 109/929 (11.7) | 31 (10.5) | 78 (12.3) | 0.429 |
Schirmer I test ≤ 5 mm/5 min, n (%) | 853 (91.3) | 287 (96.0) | 566 (89.1) | 0.001 |
Interstitial lung disease, n (%) | 360 (38.5) | 177 (59.2) | 183 (28.8) | < 0.001 |
Focus score on MSGB, M(IQR) | 517/2 (1–4) | 2 (1–4) | 3 (1–4) | 0.351 |