Table 3 Comparison of clinical features, disease activity and organ damage accrual at diagnosis and last visit
Variables | At diagnosis | At last visit | |||||
|---|---|---|---|---|---|---|---|
Late-onset SLE (N = 62) | Early-onset SLE (N = 124) | p value | Late-onset SLE (N = 62) | Early-onset SLE (N = 124) | p1 value | p2 value | |
Malar rashes | 9 (14.5) | 46 (37.1) | 0.001 | 11 (17.7) | 56 (45.2) | 0.001 | 0.152 |
Discoid rashes | 25 (40.3) | 46 (37.1) | 0.669 | 26 (41.9) | 53 (42.7) | 0.947 | 0.425 |
Oral ulcers | 13 (21.0) | 43 (34.7) | 0.055 | 14 (22.6) | 52 (41.9) | 0.024 | 0.130 |
Photosensitivity | 11 (17.7) | 21 (16.9) | 0.891 | 13 (21.0) | 26 (21.0) | 0.889 | 0.956 |
Arthritis | 26 (41.9) | 77 (62.1) | 0.009 | 32 (51.6) | 82 (66.1) | 0.081 | 0.315 |
Serositis | 23 (37.0) | 18 (14.5) | 0.001 | 24 (38.7) | 28 (22.6) | 0.011 | 0.403 |
Pleuritis, n (%) | 17 (27.4) | 14 (11.3) | 0.005 | 17 (27.4) | 17 (13.7) | 0.010 | 0.980 |
Pericarditis, n (%) | 10 (16.1) | 11 (8.9) | 0.140 | 12 (19.4) | 18 (14.5) | 0.422 | 0.779 |
Renal disorder, n (%) | 29 (46.8) | 60 (48.4) | 0.836 | 33 (53.2) | 92 (74.2) | 0.008 | 0.002 |
Neurologic disorder | 7 (11.3) | 8 (6.5) | 0.253 | 9 (14.5) | 17 (13.7) | 0.795 | 0.331 |
Seizures, n (%) | 5 (8.1) | 3 (2.4) | 0.074 | 7 (11.3) | 6 (4.8) | 0.088 | 0.684 |
Psychosis, n (%) | 2 (3.2) | 5 (4.0) | 0.785 | 2 (3.2) | 11 (8.9) | 0.226 | 0.219 |
Hematologic disorder, n (%) | 52 (83.9) | 101 (81.5) | 0.684 | 54 (87.1) | 106 (85.5) | 0.562 | 0.990 |
Hemolytic anemia, n (%) | 31 (50.0) | 42 (33.9) | 0.034 | 35 (56.5) | 60 (48.4) | 0.308 | 0.369 |
Leukopenia, n (%) | 20 (32.3) | 62 (50.0) | 0.022 | 21 (33.9) | 66 (53.2) | 0.025 | 0.418 |
Lymphopenia, n (%) | 31 (50.0) | 82 (66.1) | 0.034 | 31 (50.0) | 85 (68.5) | 0.041 | 0.198 |
Thrombocytopenia, n (%) | 15 (24.2) | 23 (18.5) | 0.368 | 16 (25.8) | 34 (27.4) | 0.938 | 0.193 |
ANA, n/N (%) | 62/62 (100.0) | 123/123 (100.0) | 1 | 62/62 (100.0) | 123/123 (100.0) | 1 | 1 |
Anti-dsDNA, n/N (%) | 37/48 (77.1) | 76/98 (77.6) | 0.949 | 38/54 (70.4) | 96/117 (82.1) | 0.149 | 0.049 |
No. of ACR criteria, mean (95% CI) | 4.82 (4.53–5.11) | 5.04 (4.81–5.27) | 0.268 | 5.26 (4.99–5.23) | 5.94 (5.69–6.18) | 0.005 | 0.008 |
mSLEDAI-2K scores, mean (95% CI)a | 7.41 (5.98-9.00) | 7.50 (6.48–8.59) | 0.927 | 0.41 (0.13–0.85) | 0.57 (0.29–0.93) | 0.006 | 0.253 |
SDI scores, mean (95% CI)a | 0.37 (0.20–0.58) | 0.02 (0.01–0.04) | < 0.001 | 1.37 (0.95–1.86) | 0.47 (0.31–0.66) | < 0.001 | 0.341 |