Fig. 2
From: The role of proteasome in muscle wasting of experimental arthritis
Etanercept treatment decreases 26S caspase-like activity compared to CIA-Vehicle and CIA-MTX groups. Proteasome activity was evaluated in GA muscle homogenates of arthritic and healthy animals, with specific inhibitors and fluorogenic substrates for chymotrypsin-like and caspase-like activity (A, B) for 26S and (C, D) 20S proteasomes. Activity is presented in % against values of CO group. CIA-Vehicle: CIA with PBS; CIA-ETN: CIA treated with etanercept; CIA-MTX: CIA treated with methotrexate. Data were analyzed by one-way ANOVA followed by Tukey’s test and are presented as mean ± SEM; n = 8 animals per group. *p < 0.05; **p < 0.01