Table 1 General characteristics of 91 adult patients with defined dermatomyositis
Characteristics | N = 91 |
|---|---|
Age at disease diagnosis (years) | 47.3 ± 15.4 |
Female gender | 61 (67.0) |
White ethnicity | 74 (81.3) |
Constitutional symptoms at baseline | 81 (89.0) |
Gottron’s sign/papules | 87 (96.7) |
Heliotrope rash | 79 (86.8) |
“V”-neck sign | 71 (78.0) |
“Shawl” sign | 56 (61.5) |
Raynaud’s phenomenon | 55 (60.4) |
Vasculitis | 26 (28.6) |
“Mechanics’ hands” | 20 (21.0) |
Skin ulcers | 15 (16.5) |
Calcinosis | 4 (4.4) |
Muscle strength (MRC) | |
Upper limbs | |
V degree | 1 (1.1) |
IV degree | 61 (67.0) |
III degree | 23 (25.3) |
II degree | 6 (6.6) |
Lower limbs | |
V degree | 5 (5.5) |
IV degree | 56 (61.6) |
III degree | 24 (26.4) |
II degree | 6 (6.6) |
Dysphagia | 67 (73.6) |
Arthritis | 30 (33.0) |
Lung involvement | 34 (37.4) |
Interstitial pneumopathy | 32 (35.2) |
Ground glass opacities | 12 (13.2) |
Pneumomediastinum | 1 (1.1) |
Maximum levels of muscle enzymes | |
Creatine phosphokinase (U/L) | 812 (177–3121) |
Aspartate aminotransferase (U/L) | 62 (26–32) |
Alanine aminotransferase (U/L) | 43 (21–98) |
Lactic dehydrogenase (U/L) | 531 (248–904) |
Antinuclear antibodies | 62 (68.2) |
Myositis-specific autoantibodies (N = 74) | |
Anti-Mi-2 | 10 (11.0) |
Anti-Jo-1 | 10 (11.0) |
Anti-MDA-5 | 10 (11.0) |
Anti-TIF-1γ | 7 (7.7) |
Anti-SAE | 6 (6.6) |
Anti-NXP-2 | 5 (5.5) |
Myositis-associated autoantibodies (N = 74) | |
Anti-Ro-52 | 26 (28.6) |
Anti-PM/Scl 75 | 3 (3.3) |
Anti-SRP | 1 (1.1) |
Anti-OJ, -EJ, PL-7, PL-12, -Ku | 3 (3.3) |