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Table 5 Reported cases of EF-like chronic GVHD

From: Graft versus host disease-related eosinophilic fasciitis: cohort description and literature review

References

Participants

Interventions scales/scores assessed

Outcomes and conclusions

Chalopin et al. [27]

Case report

46-year-old male + 227 days post-allo-HCT

Clinical features

Importance of MRI to guide biopsy

Inamoto et al [26]

Multicenter, longitudinal, prospective observational study

Case series

(extension of 2014 report) [22]

Group 1 (n = 209): fascial/articular sclerotic cGVHD > 18 years according to NIH 2005 evaluation criteria (2007–2012)

Group 2 (n = 191):

Fascial/articular sclerotic cGVHD > 18 years according to NIH 2014 evaluation criteria (2013–2017)

Evaluation every 6 months except initially at 3 months in incident cases:

NIH joint/fascial (ROM) score (range 0–3)

P-ROM (range 4–25)

PRO

Lee Symptom score

Quality of life

Physical function

Redefine therapeutic response criteria

Orzechowska et al. [21]

Case report

17-year-old male with overlap GVHD

Clinical features

Multiple joint contractures

Disability

Vukić et al. [20]

Retrospective observational study

October 2013–October 2015

n = 17 cGVHD without fascial/articular involvement

n = 12 with fascial/articular cGVHD

Comparison of clinical and functional features, laboratory parameters and scales (ROM; P-ROM, gait test and grip strength)

41% fascial/articular sclerosis

High correlation with skin involvement

Elevated C3 levels

Ganta et al. [28]

Case report and literature review of reported case

n = 13

3 small case series (2, 8 and 14) and 7 isolated case reports

Clinical features

Treatment

Update of therapeutic approach

Chu et al. [29]

Case report

51-year-old male, 3 years post-allo-HCT

Differential features with sclerodermiform cGVHD

Need for deep biopsy

Inamoto et al. [19]

Retrospective

observational study

n = 977 cGVHD

Recruited May 2000-December 2009

Development of skin, fascial or joint sclerosis

20% sclerosis

(70 (33%) only joint/fascial)

Factors associated with sclerosis

Oda et al. [36]

Retrospective observational study

Case series

January 1994–March 2005

n = 8

Incidence

Risk factors

Clinical features

Early diagnosis and treatment to avoid disability

Biopsy and MRI

Patel et al. [30]

Case report

41-year-old male + 671 days post-allo-HCT

Development of deep cutaneous sclerosis and fasciitis with joint contractures

Treatment: photopheresis

Early diagnosis

MRI

Schaffer et al. [37]

Case series

n = 2

Clinical and histological features

No cutaneous sclerosis

Sbano et al. [31]

Case report

54-year-old woman + 15 months post-allo-HCT

ANA + nucleolar ultrasonography

Photopheresis treatment

Ustun et al. [32]

Case report

35-year-old male + 1 year post-allo-HCT

Myositis and fasciitis

Importance of the biopsy

Kim et al. [33]

Case report

33-year-old woman + 20 months post-allo-HCT

Skin stiffness and arthralgias

Subsequent proximal fasciitis of upper and lower limbs

Distinctive entity

Janin et al. [38]

Retrospective observational study

Case series

01/1974–01/1991

Total n = 475

n = 14 with fasciitis

Clinical features

Biopsy

Onset with edema

Similarity to eosinophilic myalgia syndrome

Markusse 1990 [35]

Case report

49-year-old woman + 8 months post-allo-HCT

Isolated fasciitis without cutaneous involvement

Biopsy

Supra-adjacent skin without affectation

Van den Bergh et al. [34]

Case report

30-year-old woman + 365 days post-allo-HCT

Clinical, laboratory and histological features

First case of fasciitis with cGVHD entity