Table 5 Comparative analysis of the mean levels and the frequency of clinical and laboratory findings in in primary Sjögren’s Syndrome (pSS) subgroups according to anti-Ro (SSa)-positive and anti-Ro (SSa)-negative results

Age (years)

52.5 ± 13.7

60.3 ± 14.6

Sex ratio (F:M)

38:1

10:1

DES (AECG criteria)

  % of positivity

95.5

100

DMS (AECG criteria)

  % of positivity

97.4

100

ESSDAI

Median (interqualile)

8 (4 – 14)

4 (2—13.5)

Clinical exams

 CFS ≥ 3

  N = 142 and 37

   % of positivity

52.8

50

Schirmer’s test (≤ 5 mm/5 min)

 N = 148 and 37

  % of positivity

54.8

50

  Mean ± SD

9.6 ± 10.4

10.2 ± 10.4

UWSF (≤ 0.1 ml/min)

 N = 142 and 30

  % of positivity

68.8

77.5

  Mean ± SD

0.12 ± 0.21

0.12 ± 0.20

Lab exams

 RF

  N = 143 and 37

   % of positivity

48.6

13.2

ANA

 N = 154 and 39

  % of positivity

78.2

57.7

Cryoglobulinaemia

 N = 130 and 32

  % of positivity

3

0

C3 (< 0.9 g/l)

 N = 147 and 38

  % of positivity

15.4

14.3

  Mean ± SD

1.22 ± 0.31

1.30 ± 0.3

C4 (< 0.1 g/l)

 N = 147 and 38

  % of positivity

15.3

11.1

  Mean ± SD

0.24 ± 0.13

0.28 ± 0.12

LDH (> 460 IU/l)

 N = 108 and 21

  % of positivity

9.9

8.3

  Mean ± SD

300.5 ± 127.9

303.6 ± 113

B2M (> 2585 ng/ml)

 N = 141 and 34

  % of positivity

45.2

26.1

  Mean ± SD

3110 ± 2521

2201 ± 584

γ fraction (> 1.79 g/dl)

 N = 153 and 38

  % of positivity

49

13.2

  Mean ± SD

1.64 ± 0.63

1.14 ± 0.55

ESR (mm/h)

 N = 122 and 31

  Mean ± SD

28.2 ± 22.4

20.9 ± 17.1

CRP (mg/dl)

 N = 121 and 31

  % of positivity

50.4

50.0

  Mean ± SD

0.74 ± 0.94

0.68 ± 0.57

LSG biopsy (FS ≥ 1)

 N = 134 and 42

  % of positivity

87.4

97.7

 ≥ 1: < 1 ratio

7:1

42:1