Variables | pSS < 35 years | pSS 35–64 years | pSS ≥ 65 years | p value |
---|---|---|---|---|
Sex ratio (F:M) | ||||
 N = 20, 131 and 47 | 19:1 | 32:1 | 14:1 | 0.299 |
DES (AECG criteria) | ||||
 N = 20, 131 and 47 | ||||
  % of positivity | 88 | 95 | 100 | 0.090 |
DMS (AECG criteria) | ||||
 N = 20, 131 and 46 | ||||
  % of positivity | 89 | 97 | 100 | 0.008* |
ESSDAI > 5 | ||||
 N = 20, 131 and 47 | ||||
  % of positivity | 88 | 64 | 72.5 | 0.207 |
  Mean ± SD | 11.3 ± 6.3 | 9.3 ± 7.5 | 10.5 ± 8.4 | 0.273 |
Lymphadenopathy | ||||
 N = 20, 131 and 47 | ||||
  % of positivity | 35 | 8 | 14 | 0.002* |
Glandular enlargement | ||||
 N = 20, 131 and 47 | ||||
  % of positivity | 63 | 29 | 35 | 0.013* |
Clinical exams | ||||
 CFS ≥ 3 | ||||
  N = 19, 118 and 42 | ||||
   % of positivity | 36.8 | 55 | 50 | 0.321 |
Schirmer’s test (≤ 5 mm/5 min) | ||||
 N = 20, 125 and 40 | ||||
  % of positivity | 30 | 52.8 | 60 | 0.070 |
  Mean ± SD | 15.2 ± 10.4 | 9.9 ± 10.4 | 8.6 ± 10.2 | 0.035* |
TFBUT (sec) | ||||
 N = 16, 105 and 36 | ||||
  % of positivity | 68.7 | 86.7 | 86.1 | 0.171 |
  Mean ± SD | 4.9 ± 3.6 | 3.4 ± 2.9 | 3.9 ± 3.0 | 0.224 |
UWSF (ml/min) | ||||
 N = 20, 112 and 40 | ||||
  % of positivity | 65 | 69.4 | 76.3 | 0.617 |
  Mean ± SD | 0.13 ± 0.13 | 0.13 ± 0.22 | 0.09 ± 0.13 | 0.055 |
Lab exams | ||||
 Anti-Ro (SSa) | ||||
  N = 20, 131 and 47 | ||||
   % of positivity (ratio) | 90 (9:1) | 81 (4:1) | 67 (2:1) | 0.031* |
   Mean ± SD | 144.3 ± 71.5 | 124.8 ± 74.2 | 112.4 ± 88.3 |  |
Anti-La (SSb) | ||||
 N = 18, 124 and 44 | ||||
  % of positivity (ratio) | 67 (2:1) | 44 (1:1.25) | 31 (1:2.2)* | 0.014* |
  Mean ± SD | 52.4 ± 47.5 | 55.1 ± 68.8 | 48.3 ± 74.2 |  |
RF | ||||
 N = 18, 118 and 44 | ||||
  % of positivity (ratio) | 56 (1.3:1) | 41.5 (1:1.4) | 34 (1:1.9) | 0.216 |
ANA | ||||
 N = 18, 131 and 44 | ||||
  % of positivity | 75 | 64 | 77 | 0.307 |
Cryoglobulinaemia | ||||
 N = 18, 111 and 33 | ||||
  % of positivity | 0 | 1.7 | 6.1 | 0.255 |
C3 (< 0.9 g/l) | ||||
 N = 18, 127 and 40 | ||||
  % of positivity | 15.4 | 14.4 | 15.8 |  |
  Mean ± SD | 1.2 ± 0.28 | 1.2 ± 0.32 | 1.2 ± 0.34 | 0.411 |
C4 (< 0.1 g/l) | ||||
 N = 18, 127 and 40 | ||||
  % of positivity | 14.8 | 13.6 | 18.4 |  |
  Mean ± SD | 0.23 ± 0.13 | 0.24 ± 0.1 | 0.25 ± 0.2 | 0.597 |
LDH (> 460 IU/l) | ||||
 N = 18, 80 and 31 | ||||
  % of positivity | 6.2 | 10.1 | 10 |  |
  Mean ± SD | 295 ± 89.5 | 305 ± 117.5 | 316 ± 124.5 | 0.812 |
B2M (> 2585 ng/ml) | ||||
 N = 15, 123 and 37 | ||||
  % of positivity | 40 | 39 | 52 |  |
  Mean ± SD | 2230 ± 721.4 | 3075 ± 1864 | 3820 ± 4123 | 0.303 |
γ fraction (> 1.79 g/dl) | ||||
 N = 20, 131 and 40 | ||||
  % of positivity | 52.6 | 39.8 | 35.8 |  |
  Mean ± SD | 1.71 ± 0.69 | 1.53 ± 0.61 | 1.30 ± 0.77 | 0.029* |
ESR (mm/h) | ||||
 N = 20, 106 and 27 | ||||
  Mean ± SD | 27 ± 18.4 | 25 ± 20.3 | 35 ± 27.3 | 0.151 |
CRP | ||||
 N = 19, 105 and 28 | ||||
  % of positivity | 52.6 | 51.1 | 50.0 |  |
  Mean ± SD | 1.0 ± 0.9 | 0.8 ± 0.9 | 0.5 ± 0.4 | 0.219 |
LSG biopsy (FS ≥ 1) | ||||
 N = 18, 120 and 38 | ||||
  % of positivity | 96 | 88 | 97 | 0.059 |