Fig. 3From: Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritisDuration and dose-down of anti-FnEDA biodistribution in mCIA joint tissue. Dosed anti-FnEDA mAb detected by IHC in joints of naïve animal (A) and mCIA animal after 48 h (B), 6 days (C) and 13 days (D). For dose-down study, i.v. injection was administered to mCIA animals at: 3 mg/kg (E), 1 mg/kg (F), 0.3 mg/kg (G) and 0.1 mg/kg (H). (N = 3, Arrows point to disease specific structures, magnification level is noted in each picture)Back to article page