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Fig. 1 | Advances in Rheumatology

Fig. 1

From: Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritis

Fig. 1

(A) Biodistribution of anti-FnEDA-IR800 in mice. Binding analysis of anti-FnEDA mAb (blue triangle), IR800 labeled anti-FnEDA mAb (green circle) and isotype control anti-TeTx mAb (red square), (N = 3 for each data point, with standard deviation bars). (B) MFI plots of anti-FnEDA-IR800 in organs of naïve versus CIA mice, showing significant difference between MFI values between naïve paws and mCIA paws (N = 3, p < 0.001). (C) Comparison between non-specific anti-TeTx-IR800 and anti-FnEDA-IR800, showing significant difference between MFI values of anti-FnEDA-IR800 and non-specific anti-Tetx-IR800 in mCIA paws (N = 3, p < 0.01). (D) Representative ex vivo images of organs from mCIA animals dosed with anti-FnEDA-IR800, (F) naïve animals dosed with anti-FnEDA-IR800 (E), and mCIA animals dosed with anti-TeTx-IR800 (F)

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