Chronic use of hydroxychloroquine did not protect against COVID-19 in a large cohort of patients with rheumatic diseases in Brazil

Table 4 Final logistic regression model considering all individuals enrolled at baseline

Variables	Binary analysis			Multivariate analysis
	No symptoms N = 7720	Clinically Confirmed COVID-19 N = 293	p	OR (95% CI)	P***
	n (%)	n (%)	p	OR (95% CI)	P***
Age (y), mean (SD); med. (min–max.)	43.9 (15.2); 42 (18–98)	41.6 (13.0); 41 (18–90)	0.028*	0.989 (0.981; 0.997)	0.008
Group
Household cohabitants	3691 (47.8)	124 (42.3)	0.065**	1	-
RD patients	4029 (52.2)	169 (57.7)		1.10 (0.83; 1.46)	0.526
Sex
Women	5259 (68.2)	218 (75.4)	0.01**	1	-
Men	2450 (31.8)	71 (24.6)		0.71 (0.52; 0.98)	0.043
Schooling
Basic or illiterate	2110 (27.4)	64 (21.8)	0.091**
High school	3280 (42.6)	139 (47.4)
College	2317 (30.1)	90 (30.7)
Family in social distancing	4728 (61.3)	172 (58.9)	0.402**
Heart disease	398 (5.3)	17 (6)	0.570**
Diabetes	585 (7.7)	17 (6)	0.292**
Lung disease	367 (4.8)	21 (7.4)	0.048**	1.63 (1.03; 2.58)	0.038
Kidney disease	465 (6.1)	23 (8.2)	0.169**
Hypertension	2165 (28.6)	78 (27.7)	0.730**
Influenza vaccine within 30 last days	2138 (27.8)	63 (21.6)	0.022**

Bold values indicate statistical significance (p < 0.05)
Outcome is clinically confirmed COVID-19 diagnosis
Y, years; SD, standard deviation; med., median; min., minimum; max., maximum
^*Mann–Whitney test; **Chi-square test; ***Wald test by final logistic regression model

ISSN: 2523-3106