Table 4 Association between anti-rheumatic and psychotropic therapy and depression (n = 490)
Therapy | Total sample (n = 490) | Depression according to HADS-D (cut-off ≥ 11) | p-value (Chi-square or t test) | |
|---|---|---|---|---|
Not depressed (n = 420) | Depressed (n = 70) | |||
RA therapy | ||||
Corticosteroids, n (%) | 242 (49.4%) | 200 (47.6%) | 42 (60.0%) | 0.050 |
NSAIDs (> 10 per month), n (%) | 104 (21.2%) | 81 (19.3%) | 23 (32.9%) | 0.010 |
Vitamin D, n (%) | 388 (79.2%) | 328 (78.1%) | 60 (85.7%) | 0.146 |
Anti-rheumatic drugs | ||||
Only cDMARDS, n (%) | 199 (40.6%) | 170 (40.5%) | 29 (41.4%) | 0.937 |
Only anti-TNFα, n (%) | 67 (13.7%) | 57 (13.6%) | 10 (14.3%) | |
cDMARDS plus anti-TNFα, n (%) | 105 (21.4%) | 92 (21.9%) | 13 (18.6%) | |
No cDMARDS, no anti-TNFα, n (%) | 119 (24.3%) | 101 (24.0%) | 18 (25.7%) | |
Psychotropic therapy | ||||
Antidepressants, n (%) | 30 (35.9%) | 19 (4.5%) | 11 (15.7%) | < 0.001 |
Total number of drugs, mean (sd) | 5.2 (2.5) | 5.0 (2.4) | 6.4 (2.8) | < 0.001 |