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Table 1 Methodological quality assessment and strength of evidence

From: Intestinal microbiota and active systemic lupus erythematosus: a systematic review

Study (year)

Conflict of Interests

Ethical Approval

Downs and Black checklist

GRADE

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Total

Score#

Chen at al. 2020

No

Yes

1

1

1

0

1

1

1

1

1

1

1

1

1

1

0

1

14

80%

He at al. 2016

No

Yes

1

1

1

0

1

1

_

1

1

1

1

1

1

1

0

_

12

80%

Li at al. 2019

No

Yes

1

1

1

0

1

1

1

1

1

1

1

1

1

1

0

1

14

80%

Luo at al. 2018

No

*

1

1

1

0

1

1

1

1

1

1

1

1

1

0

0

1

13

76%

Hevia at al. 2014

*

Yes

1

1

1

0

1

1

_

1

1

1

_

1

1

_

0

_

10

76%

  1. Downs and Black checklist: A) objective clearly stated; B) main outcomes clearly described; C) sample characteristics clearly defined; D) distribution of principal confounders clearly described; E) main findings clearly defined; F) random variability in estimates provided; G) lost to follow-up described; H) probability values reported; I) sample target representative of population; J) sample recruitment representative of population; K) analyses adjusted for different follow-up duration; L) statistical tests appropriately used; M) primary outcomes valid/reliable; N) sample recruited from the same population; O) adequate adjustment for confounding; and P) losses of sample to follow-up taken into account (corresponding to questions 1–3, 5–7, 9–12, 17,18, 20, 21, 25,26). Questions G and P were applied only for longitudinal studies. Questions K and N were applied only for case-control and longitudinal studies
  2. # Score reaches 100% with 13, 15, and 17 points for cross-sectional, case-control, and longitudinal studies, respectively
  3. *, not reported, −, not applied
  4. GRADE, Grading of Recommendations, Assessment, Development and Evaluations; one filled circle, very low quality; two filled circles, low quality; three filled circles, moderate quality; four filled circles, high quality