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Table 4 Relation between YKL-40 serum levels and others variables (demographic, clinical, laboratory and lung parameters, disease status, and comorbidities) of the patients with antisynthetase syndrome

From: High YKL-40 serum levels and its expression in the muscle tissues of patients with antisynthetase syndrome

  Group 1 Group 2 P value
  n Mean ± SD n Mean ± SD  
Demographic data
 Gender (female) 53 628.5 ± 363.6 11 691.3 ± 461.0 0.658
 Ethnicity (Caucasian) 47 572.5 ± 316.7 17 793.2 ± 468.2 0.111
Clinical parameters
 Fever 18 579.4 ± 343.8 46 664.3 ± 394.0 0.484
 Raynaud phenomenon 14 536.6 ± 361.8 50 677.4 ± 382.7 0.255
 “Mechanic’s hands” 7 658.6 ± 334.6 57 637 ± 389.2 0.891
 Muscle involvement 3 980.2 ± 178.7 61 625.6 ± 379.2 0.198
 Joint involvement 5 973.5 ± 602.1 59 610.4 ± 347.5 0.066
Laboratory parameters
 Antinuclear factor 12 685.7 ± 303.5 52 628.4 ± 398.4 0.674
 Anti-Ro-52 35 663.9 ± 406.5 28 638.5 ± 348.0 0.818
 Anti-Jo-1 11 728.4 ± 455.9 53 617.4 ± 359.7 0.414
 Anti-PL-7 60 619.1 ± 377.6 4 876.1 ± 351.5 0.197
 Anti-PL-12 60 627.2 ± 360.9 4 784.8 ± 595.5 0.431
 Anti-EJ 61 653.7 ± 380.8 3 320.4 ± 52.2 0.227
Lung involvement
 Ground-glass 18 658.2 ± 348.1 46 634.2 ± 392.6 0.851
 Incipient pneumopathy 24 695.9 ± 387.1 40 607.6 ± 376.4 0.437
 Pulmonary fibrosis 50 586.2 ± 335.7 14 826.2 ± 471.8 0.063
Treatment
 Prednisone (current use) 17 483.3 ± 222.6 46 684.2 ± 406.3 0.047
Immunosuppressives/biologicals
 Azathioprine 43 618.9 ± 354.7 21 676.5 ± 425.2 0.613
 Mycophenolate mofetil 54 648.4 ± 383.8 10 603.1 ± 375.2 0.750
 Methotrexate 52 606.3 ± 338.1 12 790.3 ± 521.9 0.337
 Antimalarial 61 645.3 ± 385.8 3 516.7 ± 91.7 0.643
 Leflunomide 62 642.1 ± 382.5 2 544.0 ± 0 0.801
 Cyclosporine 62 650.8 ± 381.1 2 388.7 ± 272.8 0.343
 Cyclophosphamide 63 644.0 ± 381.8 1 451.9 ± 0 0.621
 Rituximab 48 690.0 ± 364.8 16 537.0 ± 397.9 0.188
Comorbidities
 Systemic arterial hypertension 42 590.4 ± 379.9 22 742.5 ± 366.9 0.190
 Diabetes mellitus 52 645.1 ± 395.0 12 610.0 ± 283.2 0.823
 Hypothyroidism 61 628.0 ± 381.0 3 922.5 ± 205.8 0.286
 Acute myocardial infarction 61 641.6 ± 382.6 3 567.2 ± 0 0.848
 Stroke 63 645.2 ± 381.0 1 391.6 ± 0 0.513
  1. SD standard deviation