Table 2 Characteristics and results of the selected experimental models of systemic sclerosis
From: Dualities of the vitamin D in systemic sclerosis: a systematic literature review
Author | Year | Research Design | Main results |
|---|---|---|---|
Slominski et al. [44] | 2013 | Culture of skin fibroblasts from patients and controls | Efficacy of vitamin D in inhibiting TGF-induced collagen synthesis and inhibiting cell proliferation in fibroblasts from patients and controls; vitamin D suppressed fibrogenesis in a bleomycin-induced sclerosis model. |
Terao et al. [45] | 2015 | Experimental model | Effect of vitamin D analogue on periostin expression in fibroblasts and bleomycin-induced sclerosis model; maxacalcitol reduces the expression of periostin and TGF-β and suppresses the Th2 response. |
Usategui et al. [46] | 2014 | Cutaneous fibrosis in animal model | Effect of the topical analogue of vitamin D (calcipotriol) on cytokines and the development of fibrosis in rats with bleomycin-induced sclerosis; calcipotriol overexpressed Th2 axis expression, with antifibrotic effect. |
Zerr et al. [47] | 2014 | Culture of skin fibroblasts from patients and controls | Expression of VDR in experimental model and fibroblasts; effect of paricalcitol on bleomycin-induced fibrosis model and overexpression of TGF-β receptor (TBRICA); VDR characterization as a negative regulator of TGF-β / Smad pathway signaling. |