Fig. 2

LncRNA KCNQ1OT1 can directly bind to miR-126-5p. a The binding sequences between KCNQ1OT1 and miR-126-5p were predicted by starbase. b The interaction between KCNQ1OT1 and miR-126-5p in CHON-001 cells was verified by dual-luciferase reporter (DLR) assay. ^**P < 0.01, vs. mimics NC. c Relative expression of miR-126-5p was detected by qRT-PCR in CHON-001 cells. ^***P < 0.001, vs. sh-NC. ^###P < 0.001, vs. pcDNA3.1-NC. d Relative expression of miR-126-5p was detected by qRT-PCR in cartilage tissues of PTOA patients and normal cartilage tissues. ^***P < 0.001, vs. Control. e The correlation between KCNQ1OT1 and miR-126-5p was analyzed by Pearson’s correlation analysis in cartilage tissues of PTOA patients. P = 0.0171. R² = 0.2422