Fig. 1

LncRNA KCNQ1OT1 promotes cell viability and migration, and suppresses ECM degradation in CHON-001 cells. a Relative expression of KCNQ1OT1 was detected by qRT-PCR in cartilage tissues of PTOA patients and normal cartilage tissues. ^***P < 0.001, vs. Control. b Relative expression of KCNQ1OT1 was determined by qRT-PCR in CHON-001 cells. ^***P < 0.001, vs. sh-NC. ^###P < 0.001, vs. pcDNA3.1-NC. c The cell viability was determined by MTT assay in CHON-001 cells. ^***P < 0.001, vs. sh-NC. ^###P < 0.001, vs. pcDNA3.1-NC. d Relative migration was assessed by transwell assay in CHON-001 cells. ^**P < 0.01, vs. sh-NC. ^##P < 0.01, vs. pcDNA3.1-NC. e Relative protein expression of collagen II and MMP13 was determined by western blot in CHON-001 cells. ^**P < 0.01, ^***P < 0.001, vs. sh-NC. ^##P < 0.01, ^###P < 0.001, vs. pcDNA3.1-NC