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Table 3 Comparison of the qualitative variables according to the BDNF Val66Met genotypes

From: The genetic influence of the brain-derived neurotrophic factor Val66Met polymorphism in chronic low back pain

 

Genotype

 
 

Val/ Val

N (%)

Val/Met

N (%)

P-value

Gender

 Female

45 (55.6)

16 (61.5)

0.59

 Male

36 (44.4)

10 (38.6)

 

Civil status

 Living alone

42 (51.8)

11 (42.3)

0.40

 Living with partner

39 (48.2)

15 (57.7)

 

Ethnicity

 White

14 (18.2)

8 (34.8)

 

 Brown

46 (59.7)

13 (56.5)

0.14

 Black

17 (22.1)

2 (8.7)

 

Schooling

 Until high school

63 (77.8)

16 (64.0)

0.17

 Complete high school

18 (22.2)

9 (36.0)

 

Have children

 No

19 (23.5)

6 (23.1)

0.97

 Yes

62 (76.5)

20 (76.9)

 

Healthy

 Good, very good, or great

35 (44.3)

12 (46.1)

0.87

 Regular, bad, or lousy

44 (55.7)

14 (53.9)

 

Chronicity pain

 3–12 months

21 (25.9)

5 (19.2)

 

 13–60 months

27 (33.3)

13 (50.0)

0.31

  > 60 months

33 (40.8)

8 (30.8)

 

Pain intensity

 Least

8 (9.9)

4 (15.4)

 

 Moderate

14 (17.3)

3 (11.5)

0.62

 Intense

59 (72.8)

19 (73.1)

 

Pain duration in the month

 Intermittent

37 (46.2)

15 (65.2)

0.11

 Constant

43 (53.8)

8 (34.8)

 

Comorbidities

 No

46 (56.8)

16 (61.5)

0.67

 Yes

35 (43.2)

10 (38.5)

 

Physical activity

 Inactive

55 (67.9)

18 (69.2)

 

 Insufficiently active

8 (9.9)

4 (15.4)

0.80

 Moderately active

13 (16.0)

3 (11.5)

 

 Vigorously active

5 (6.2)

1 (3.9)

 

Smoking

 No

68 (91.9)

21 (91.3)

0.93

 Yes

6 (8.1)

2 (8.7)

 

Alcoholism

 No

66 (89.2)

22 (95.7)

0.35

 Yes

8 (10.8)

1 (4.3)

 

Satisfaction

 Unsatisfied or a little satisfied

33 (51.6)

9 (40.9)

0.39

 Satisfied or much satisfied

31 (48.4)

13 (59.1)

 

Occupational situation

 Active/employed

62 (76.5)

18 (69.2)

0.45

 Unemployed

19 (23.5)

8 (30.8)

 

Low back pain in family history

 No

36 (44.4)

12 (46.2)

0.88

 Yes

45 (55.6)

14 (53.8)

 

Overweight/obesity

 No

32 (41.0)

11 (42.3)

0.91

 Yes

46 (59.0)

15 (57.7)

 

CSI

 No

14 (17.3)

4 (15.4)

0.82

 Yes

67 (82.7)

22 (84.6)

 

RMDQ

 No

28 (34.6)

9 (34.6)

0.97

 Yes

53 (65.4)

17 (65.4)

 

Medication

 Non opioid

33 (62.3)

12 (80.0)

0.20

 Weak opioid

20 (37.7)

3 (20.0)

 

Medication frequency

 Every 6 h

35 (66.0)

7 (50.0)

0.27

 If there is pain

18 (34.0)

7 (50.0)

 

Start of medication

 12 months ago

32 (68.1)

8 (80.0)

 

 13–60 months

7 (14.9)

1 (10.0)

0.75

 More than 60 months

8 (17.0)

1 (10.0)

 

Relief of pain with medication

 50% relief

32 (62.8)

5 (45.5)

0.29

 More than 50% relief

19 (37.2)

6 (54.5)

 

Tampa score

 Light

7 (8.6)

2 (7.7)

 

 Moderate

47 (58.1)

14 (53.8)

0.89

 Critical

27 (33.3)

10 (38.5)

 

HADS-anxiety

 No

34 (42.0)

11 (42.3)

0.98

 Yes

47 (58.0)

15 (57.7)

 

HADS-depression

 No

53 (65.4)

20 (76.9)

0.27

 Yes

28 (34.6)

6 (23.1)

 
  1. CSI central sensitization inventory, HADS hospital anxiety and depression scale, RMDQ Rolland-Morris disability questionnaire
  2. P-value for the Chi-square test