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Table 1 Characteristics of individual studies included

From: Association of homocysteine with ankylosing spondylitis: a systematic review and meta-analysis

First author, year Region AS Control    
Age (year) (mean ± sd) BMI Sex ratio (M/F) BASDAI Duration (year) (mean ± sd) Age (year) (mean ± sd) BMI Sex ratio (M/F) Assay method, sample Study type Criteria for the classification NOS
Shu JL, 2020 [16] Mainland China 41.6 ± 8.6 NA 30/5 NA NA 39.7 ± 14.4 NA 36/5 NA CS ACR 7
Geçene M, 2013 [39] Turkey 36.7 ± 4.8 24.9 ± 3.1 50/0 2.4 ± 1.7 NA 36.3 ± 4.7 25.0 ± 3.0 50/0 HPLC, plasma CS ACR 7
Mao N, 2012 [34] Mainland China NA NA NA NA NA NA NA NA ELISA, plasma CS ACR 7
Capkin E, 2012 [40] Turkey 36.4 ± 11.2 NA 88/20 3.7 ± 1.6 8.4 ± 5.6 38.2 ± 13.0 NA 49/16 ELISA, plasma CS ACR 7
Başkan BM, 2009 [35] Turkey 40.1 ± 11.0 NA NA 4.2 ± 1.7 10.0 ± 7.7 38.1 ± 0.6 NA NA NA CS ACR 7
Gonzalez-Lopez L, 2008 [36] Mexico 39.9 ± 8.4 26.0 ± 2.8 73/24 5.4 ± 2.1 7.8 ± 6.0 38.9 ± 7.8 25.8 ± 4.2 73/24 FPIA, Serum CSS ACR 8
Wei JC, 2007 [37] Taiwan, China NA NA NA NA NA NA NA NA ELISA, plasma CSS ACR 7
Malesci D, 2007 [41] Italy 47.6 ± 11.8 29.5 ± 4.4 21/3 2.7 ± 1.8 18.5 ± 10.8 49.6 ± 6.0 NA 16/3 NA CS ACR&ESSG 8
Xu XY, 2005 [38] Mainland China 32.1 ± 13.7 NA 44/16 NA NA 30.8 ± 19.7 NA 30/32 FPIA, plasma CS ACR 7
  1. AS Ankylosing spondylitis, BMI Body mass index, BASDAI Bath AS disease activity index, NOS Newcastle-Ottawa Scale, NA Not available, HPLC High performance liquid chromatography, ELISA Enzyme-linked immunosorbent assays, FPIA Fluorescence polarization immunoassay, CS Case control, CSS Cross-sectional study, ACR American College of Rheumatology, ESSG European Spondyloarthropathy Study Group